ID   A0A0T5PES2_9RHOB        Unreviewed;       295 AA.
AC   A0A0T5PES2;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Dihydrodipicolinate synthetase {ECO:0000313|EMBL:KRS19422.1};
GN   ORFNames=XM52_00825 {ECO:0000313|EMBL:KRS19422.1};
OS   Roseovarius indicus.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseovarius.
OX   NCBI_TaxID=540747 {ECO:0000313|EMBL:KRS19422.1, ECO:0000313|Proteomes:UP000051401};
RN   [1] {ECO:0000313|EMBL:KRS19422.1, ECO:0000313|Proteomes:UP000051401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B108 {ECO:0000313|EMBL:KRS19422.1,
RC   ECO:0000313|Proteomes:UP000051401};
RA   Li G., Lai Q., Shao Z., Yan P.;
RT   "The draft genome sequence of Roseovarius indicus B108T.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRS19422.1}.
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DR   EMBL; LAXI01000001; KRS19422.1; -; Genomic_DNA.
DR   RefSeq; WP_057812300.1; NZ_LAXI01000001.1.
DR   AlphaFoldDB; A0A0T5PES2; -.
DR   STRING; 540747.SAMN04488031_102395; -.
DR   PATRIC; fig|540747.5.peg.167; -.
DR   OrthoDB; 199953at2; -.
DR   Proteomes; UP000051401; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051401}.
FT   ACT_SITE        137
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        165
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         49
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
FT   BINDING         207
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   295 AA;  31981 MW;  5893154BE276A575 CRC64;
     MTQNDFHGVF PYLVSPIDDR GRVMDHVLDR LCDDLIGKGV HGLTPLGSTG EFAYLDWAQK
     REIVATVVRA TGRRVPVVAG VAATTIAEAQ RQTEAFETLG ADGILAVMEA YFPVGDEGTY
     AYFKAIAEAT SLPVVLYTNP NFQRSDLSLP VLERLSEIEN IRYLKDASSN TGRLLSIMNR
     VGGKIEVFSA SAHIPTCVMM IGGVGWMAGP ACLVPEQSVE LYELCRAGQW DKAMELQRKL
     WGLNQAFARH NLAACIKGGL EMQGYEVGVP LPPQAPLSDE GRAEVRAALE AVGAL
//