ID A0A0T6AQR5_9BACT Unreviewed; 390 AA.
AC A0A0T6AQR5;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADPH) {ECO:0000313|EMBL:KRT77095.1};
DE EC=1.1.1.34 {ECO:0000313|EMBL:KRT77095.1};
GN ORFNames=XU14_C0021G0021 {ECO:0000313|EMBL:KRT77095.1};
OS Armatimonadetes bacterium CSP1-3.
OC Bacteria; Armatimonadota.
OX NCBI_TaxID=1640515 {ECO:0000313|EMBL:KRT77095.1, ECO:0000313|Proteomes:UP000051026};
RN [1] {ECO:0000313|EMBL:KRT77095.1, ECO:0000313|Proteomes:UP000051026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CSP1-3 {ECO:0000313|EMBL:KRT77095.1};
RA Hug L.A., Thomas B.C., Sharon I., Brown C.T., Sharma R., Hettich R.L.,
RA Wilkins M.J., Williams K.H., Singh A., Banfield J.F.;
RT "Critical biogeochemical functions in the subsurface are associated with
RT bacteria from new phyla and little studied lineages.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRT77095.1}.
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DR EMBL; LDXQ01000021; KRT77095.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0T6AQR5; -.
DR PATRIC; fig|1640515.3.peg.1033; -.
DR Proteomes; UP000051026; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KRT77095.1}.
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 39929 MW; 10316262A549E929 CRC64;
MPDSRPHDTP HPPPGRGGPE VPAGGFRLPP TRARAPDALA DPLLQTQSAW AGEHLQDFIG
SVRIPVGIAG PLRVNGLSAR GDYSLPLATT DPGFIAACNR GLQVMAEAGG CTAMVLDAGI
GRGLTFGFRT LQQAGLFAHW VISHVDTFRR VAAASSAEAR LIDLRVTVVS NLVHAYCEFA
SGDAVDGEAG AAADAIRAYV RKHCPVRPLE AARVSPAPLP GGLLPTPTVQ GRRVSAEVIL
PADLVVARLE TTVQQIATAW RGPAGDAANA PPGAPRWPVR ALAALFAACG QELAGAAASA
AGLYRFEVTP QGELYAGVTL PHLMVGTVGG GTALPAQRAC LDLLGLAGPG KAPALAEVCA
GLCLAAELAA LAGLSEGSRR PQPFTITKEG
//
