ID A0A0T6AVK8_9SCAR Unreviewed; 1123 AA.
AC A0A0T6AVK8;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=FACT complex subunit {ECO:0000256|RuleBase:RU367052};
GN ORFNames=AMK59_6543 {ECO:0000313|EMBL:KRT79094.1};
OS Oryctes borbonicus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC Scarabaeidae; Dynastinae; Oryctes.
OX NCBI_TaxID=1629725 {ECO:0000313|EMBL:KRT79094.1, ECO:0000313|Proteomes:UP000051574};
RN [1] {ECO:0000313|EMBL:KRT79094.1, ECO:0000313|Proteomes:UP000051574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OB123 {ECO:0000313|EMBL:KRT79094.1};
RC TISSUE=Whole animal {ECO:0000313|EMBL:KRT79094.1};
RA Meyer J.M., Markov G.V., Baskaran P., Herrmann M., Sommer R.J.,
RA Roedelsperger C.;
RT "Draft genome of the scarab beetle Oryctes borbonicus.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the FACT complex, a general chromatin factor
CC that acts to reorganize nucleosomes. The FACT complex is involved in
CC multiple processes that require DNA as a template such as mRNA
CC elongation, DNA replication and DNA repair. During transcription
CC elongation the FACT complex acts as a histone chaperone that both
CC destabilizes and restores nucleosomal structure. It facilitates the
CC passage of RNA polymerase II and transcription by promoting the
CC dissociation of one histone H2A-H2B dimer from the nucleosome, then
CC subsequently promotes the reestablishment of the nucleosome following
CC the passage of RNA polymerase II. {ECO:0000256|RuleBase:RU367052}.
CC -!- SUBUNIT: Component of the FACT complex.
CC {ECO:0000256|RuleBase:RU367052}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367052}.
CC Chromosome {ECO:0000256|RuleBase:RU367052}.
CC -!- SIMILARITY: Belongs to the peptidase M24 family. SPT16 subfamily.
CC {ECO:0000256|ARBA:ARBA00010779, ECO:0000256|RuleBase:RU367052}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRT79094.1}.
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DR EMBL; LJIG01022714; KRT79094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0T6AVK8; -.
DR OrthoDB; 169847at2759; -.
DR Proteomes; UP000051574; Unassembled WGS sequence.
DR GO; GO:0035101; C:FACT complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd01091; CDC68-like; 1.
DR Gene3D; 2.30.29.150; -; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR Gene3D; 2.30.29.210; FACT complex subunit Spt16p/Cdc68p; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR029148; FACT-Spt16_Nlobe.
DR InterPro; IPR013953; FACT_Spt16.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013719; RTT106/SPT16-like_middle_dom.
DR InterPro; IPR040258; Spt16.
DR InterPro; IPR048969; SPT16_C.
DR InterPro; IPR033825; Spt16_M24.
DR PANTHER; PTHR13980; CDC68 RELATED; 1.
DR PANTHER; PTHR13980:SF15; FACT COMPLEX SUBUNIT SPT16; 1.
DR Pfam; PF14826; FACT-Spt16_Nlob; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF08512; Rttp106-like_middle; 1.
DR Pfam; PF08644; SPT16; 1.
DR Pfam; PF21091; SPT16_C; 1.
DR SMART; SM01285; FACT-Spt16_Nlob; 1.
DR SMART; SM01287; Rtt106; 1.
DR SMART; SM01286; SPT16; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367052};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU367052};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU367052};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU367052};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367052};
KW Reference proteome {ECO:0000313|Proteomes:UP000051574};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367052};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU367052}.
FT DOMAIN 5..166
FT /note="FACT complex subunit Spt16 N-terminal lobe"
FT /evidence="ECO:0000259|SMART:SM01285"
FT DOMAIN 531..691
FT /note="FACT complex subunit Spt16"
FT /evidence="ECO:0000259|SMART:SM01286"
FT DOMAIN 808..898
FT /note="Histone chaperone RTT106/FACT complex subunit SPT16-
FT like middle"
FT /evidence="ECO:0000259|SMART:SM01287"
FT REGION 433..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..982
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1032
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 127935 MW; F92FE5C6C50EDCCB CRC64;
MAINLDKDTF YRRLKKLHAA WQKSEGENGF SKMDCLLTAV GVDEEIVYSK SGALQTWLMG
YELTDTIMVL TENTLYFLAS KKKIDFLRQA ENNKEENSVA LKLLTRDRTD KDENNFKTLI
SAIKGSKKGK TIGTFSKENY PGEFMDSWRA ALKKEELATI DVSSAVAYVI SPKEDTEILT
IKKACMVTVD VFTKYLKDQI MEIIDSDKKV KHSKLAEGVE VAITDKKYIS GVDTTQIDMC
YPAIIQSGGN YSLKFSVVSD KNNLHFGAII CSLGARYKSY CSNIVRTLLV NPSDEIQNNY
NFLLNLEEEV LKKLSSGTKL SEVYEAGVSY VKKEKADLIE NLTKSFGFAM GIEFKENSLT
IGPKTTAIAR KGMVFNVNMG FSNLQNKEAS DKEGKVYALF IGDTVIVNEN QPASVLTISK
KKIKNIGIFL KDESDEEEEN DEEKENTPKP EILGRGKRTA VIESKLRSEQ TSEEKRKEHQ
KELAHQLNEK AKERLAKQSG AKDVEKVRKN TVSYKNVNQM PRVAEVKELK LYVDQKYETV
ILPIYGIPVP FHISTIKNIS QSVEGDYTYL RINFFHPGST MGKNESGTYQ QPDATFLKEV
TYRSTNTKEP GEISPPSSNL NTAFRLIKEV QRKFKTREAE EREKEDLVKQ DTLILSQNKG
NPKLKDLYIR PNIVAKRMTG SLEAHTNGFR YTSVRGDKVD ILYNNIKNAF FQPCDSEMII
LLHFHLKHAI MFGKKKHVDV QFYTEVGEIT TDLGKHQHMH DRDDLAAEQS ERELRHKLKT
AFKSFCEKVD SMTKSEIEFD TPFRELGFPG APFRSTVLLQ PTSGCLVNLT EWPPFVITLE
DVELVHFERV QFHLKNFDMV FVFKDYHRRI AMVNAIPMSM LDHVKEWLNS CDIRYSEGIQ
SLNWIKIMKT ITDDPEGFFE SGGWTFLDPE SDEEEARPSD DTEDEDEVYE PSDVESESEE
SEEDSEYSEG DTESDSATEE SLGSDEDSGK DWSDLEREAA EEDRERSRYT EQIEEGGAKK
RDRYAERHKG KNDKTRDKRK SHDKHKSSSG SSNRHSSSGR HNSSSSRHST SSSSRHHGGG
GSGRDKHSSK KDSPNKDKHR SSNDKKRSRD ESGDKHRSKR SRK
//