ID A0A0T6B458_9SCAR Unreviewed; 1218 AA.
AC A0A0T6B458;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=AMK59_4402 {ECO:0000313|EMBL:KRT82159.1};
OS Oryctes borbonicus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC Scarabaeidae; Dynastinae; Oryctes.
OX NCBI_TaxID=1629725 {ECO:0000313|EMBL:KRT82159.1, ECO:0000313|Proteomes:UP000051574};
RN [1] {ECO:0000313|EMBL:KRT82159.1, ECO:0000313|Proteomes:UP000051574}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OB123 {ECO:0000313|EMBL:KRT82159.1};
RC TISSUE=Whole animal {ECO:0000313|EMBL:KRT82159.1};
RA Meyer J.M., Markov G.V., Baskaran P., Herrmann M., Sommer R.J.,
RA Roedelsperger C.;
RT "Draft genome of the scarab beetle Oryctes borbonicus.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRT82159.1}.
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DR EMBL; LJIG01009898; KRT82159.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0T6B458; -.
DR OrthoDB; 211439at2759; -.
DR Proteomes; UP000051574; Unassembled WGS sequence.
DR GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR CDD; cd05778; DNA_polB_zeta_exo; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR030559; PolZ_Rev3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR45812; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45812:SF1; DNA POLYMERASE ZETA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000051574};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 634..827
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 895..1216
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 590..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1218 AA; 138600 MW; B8738649B757089B CRC64;
MCTYKPKEKA QLKSMRKDLA PVVQFSTEDN LKLDTQNEFD TTLITPYQKV RTTMQIQHNK
IASEMDENKT NQNAISQEQN IFTPLITLNC QNIATQPPVP KQFFASLERI SPNMPRQSQK
NVGTSSQKLL QTKLVEQNRD IQIESGPSLL TPYQKQFRNM KGESQNILNT ALITPHKKEY
STLSQNDPQV YLDDTQLSSS SASLSDDIFS PNMPNSFSSE VFTPIEDKNQ EIDRQALDPA
ELYDEKNKYI PQAGTSKFTD AQKLTQISES SDEISTPKPI SLNSNGSIFT ENELKLSANS
GKDSEKSSEI DPVAPYQKEN VGFEVGEGLC KSKIESSGSE ITPYQKEQNL HRSDLILTTC
LNIFEFADQN LPSESGCKII VPKFQPPSRD FIEATMQEFN IPMESHQEPF YSDVKDVTGP
MEVGVRILKI PSNKIVDITE FESSFKGINC YRKALLEHMY PNEKITNRDI YNYKMSFCKS
TNCIIIPAKL PPSREEVELW LKSKLEKKQN ILKVIARKKI IIPCSPGADN CSDDSLTVSP
CASLDETLKN VRKITEDETS KSSLETIFDN TSTIIKKTDS LKCHRKGISQ NSSLKSNQSS
ENTFNSQELD TTKQRRRDSC QITGVTLDRT NNFAISCDNL QNAKAVSEYL HLTVFSMELI
IETRNDYKPN PSHDAIKGIV YQIFNDVPED DLRKRSVKGC FLLNNMPISP TRIKFSIVDG
IFINNDETTR IFETETDMMT KFVEFLVDCD PDILIGYEIQ MLSWGYLIER GYTLNLNLIS
LLSRVPQSTK SKPEDDLSDL TIPGRIILDF WRLLRHEIAL QSYTFENIVY HILHQRVPLY
SFRNITFWWN HVSGLYRNKV LRYYFYRVEA ILRIMDQLDL IGRTSELAKL FGIQFFEVLS
RGSQFRVESM MLRLAKPLNY IPVSPSVQQR ASMRAPESLP LIMEPESKFY VDPVIVLDFQ
SLYPSMIIAY NYCFSTCLGR IEHLGHDIPF EFGATQLKVP RKYIKRLSRK DLINISPCGV
GFVKKTVREG ILPRMLQEIL DTRLMVKKSL KKNAGNKTLE KVLDARQLGL KLIANVTYGY
TAANFSGRMP CIEVGDSVVS KGRETLQRAI NLVEKTPKWG AKVVYGDTDS IFVLVPGKSR
QEAFKIGAEI AEAVTNDNPS PVKLKLEKVF HPCILQTKKR YVGYMYESPE QDEPEYLAKG
IETVRRDGCP AVAKVGTR
//
