ID A0A0T6BPZ0_9BACI Unreviewed; 215 AA.
AC A0A0T6BPZ0;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Redox-sensing transcriptional repressor Rex {ECO:0000256|HAMAP-Rule:MF_01131};
GN Name=rex {ECO:0000256|HAMAP-Rule:MF_01131,
GN ECO:0000313|EMBL:SCA84466.1};
GN ORFNames=AB447_218165 {ECO:0000313|EMBL:KRT93712.1}, BGLY_0643
GN {ECO:0000313|EMBL:SCA84466.1}, EQZ20_03400
GN {ECO:0000313|EMBL:QAT64052.1};
OS Bacillus glycinifermentans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1664069 {ECO:0000313|EMBL:KRT93712.1, ECO:0000313|Proteomes:UP000036168};
RN [1] {ECO:0000313|EMBL:KRT93712.1, ECO:0000313|Proteomes:UP000036168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GO-13 {ECO:0000313|EMBL:KRT93712.1,
RC ECO:0000313|Proteomes:UP000036168};
RX PubMed=26297378; DOI=10.1099/ijsem.0.000462;
RA Kim S.J., Dunlap C.A., Kwon S.W., Rooney A.P.;
RT "Bacillus glycinifermentans sp. nov., isolated from fermented soybean
RT paste.";
RL Int. J. Syst. Evol. Microbiol. 65:3586-3590(2015).
RN [2] {ECO:0000313|EMBL:KRT93712.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GO-13 {ECO:0000313|EMBL:KRT93712.1};
RA Dunlap C.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SCA84466.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BGLY {ECO:0000313|EMBL:SCA84466.1};
RA Schneider J.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000093092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QAT64052.1, ECO:0000313|Proteomes:UP000288675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRCM103574 {ECO:0000313|EMBL:QAT64052.1,
RC ECO:0000313|Proteomes:UP000288675};
RA Kong H.-J., Jeong S.-Y., Jeong D.-Y.;
RT "Genome sequence of Bacillus glycinifermentans SRCM103574.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Modulates transcription in response to changes in cellular
CC NADH/NAD(+) redox state. {ECO:0000256|HAMAP-Rule:MF_01131}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01131}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01131}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Rex family.
CC {ECO:0000256|HAMAP-Rule:MF_01131}.
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DR EMBL; LECW02000020; KRT93712.1; -; Genomic_DNA.
DR EMBL; CP035232; QAT64052.1; -; Genomic_DNA.
DR EMBL; LT603683; SCA84466.1; -; Genomic_DNA.
DR RefSeq; WP_046132028.1; NZ_VHPY01000006.1.
DR AlphaFoldDB; A0A0T6BPZ0; -.
DR STRING; 1664069.BGLY_0643; -.
DR GeneID; 82851720; -.
DR KEGG; bgy:BGLY_0643; -.
DR PATRIC; fig|1664069.6.peg.682; -.
DR OrthoDB; 9784760at2; -.
DR Proteomes; UP000036168; Unassembled WGS sequence.
DR Proteomes; UP000093092; Chromosome 1.
DR Proteomes; UP000288675; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051775; P:response to redox state; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01131; Rex; 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009718; Rex_DNA-bd_C_dom.
DR InterPro; IPR022876; Tscrpt_rep_Rex.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR35786; REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX; 1.
DR PANTHER; PTHR35786:SF1; REDOX-SENSING TRANSCRIPTIONAL REPRESSOR REX; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF06971; Put_DNA-bind_N; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01131};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01131};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|HAMAP-Rule:MF_01131};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_01131};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_01131};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_01131}.
FT DOMAIN 81..181
FT /note="CoA-binding"
FT /evidence="ECO:0000259|SMART:SM00881"
FT DNA_BIND 18..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01131"
FT BINDING 92..97
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01131"
SQ SEQUENCE 215 AA; 24151 MW; BE24338000847865 CRC64;
MNLDHSKIPQ ATAKRLPLYY RFLKNLHASG KQRVSSAELS DAVKVDSATI RRDFSYFGAL
GKKGYGYNVN YLLSFFRKTL DQDEMTNVTL IGVGNLGTAF LHYNFIKNNN TKISMAFDIN
ESKIGKEVGG VPVYDLNDLE KHLTNDIPVA ILTVPAQAAQ PITDRLVALG IKGILNFTPA
RLNVPEHIRI HHIDLAVELQ SLVYFLKHYS MTEEK
//
