ID A0A0T7BPD4_9CYAN Unreviewed; 310 AA.
AC A0A0T7BPD4;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE AltName: Full=Galactowaldenase {ECO:0000256|ARBA:ARBA00033067};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN ORFNames=IJ00_06270 {ECO:0000313|EMBL:AKG20956.1};
OS Calothrix sp. 336/3.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Calotrichaceae;
OC Calothrix.
OX NCBI_TaxID=1337936 {ECO:0000313|EMBL:AKG20956.1, ECO:0000313|Proteomes:UP000065745};
RN [1] {ECO:0000313|EMBL:AKG20956.1, ECO:0000313|Proteomes:UP000065745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=336/3 {ECO:0000313|EMBL:AKG20956.1,
RC ECO:0000313|Proteomes:UP000065745};
RX PubMed=25614574;
RA Isojarvi J., Shunmugam S., Sivonen K., Allahverdiyeva Y., Aro E.M.,
RA Battchikova N.;
RT "Draft genome sequence of calothrix strain 336/3, a novel h2-producing
RT cyanobacterium isolated from a finnish lake.";
RL Genome Announc. 3:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
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DR EMBL; CP011382; AKG20956.1; -; Genomic_DNA.
DR RefSeq; WP_035151072.1; NZ_CP011382.1.
DR AlphaFoldDB; A0A0T7BPD4; -.
DR STRING; 1337936.IJ00_06270; -.
DR KEGG; calh:IJ00_06270; -.
DR eggNOG; COG1087; Bacteria.
DR OrthoDB; 9811743at2; -.
DR Proteomes; UP000065745; Chromosome.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Reference proteome {ECO:0000313|Proteomes:UP000065745}.
FT DOMAIN 4..239
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 310 AA; 33918 MW; 9F0A6C1353408E38 CRC64;
MHFVVTGGAG FIGSHLTEQL LTEGHTVTIV DNLTTGRLTN LSEHPRLKLL LKNILDCQPE
DFTQPINGIA HLAATPSVTQ SWDKPLESHH NNLSAIIAVL VLCQVLNIPR LVFASSAAVY
GNKAYLPISE EQQTSPISPY GLQKLVSEQY ANLFAKKLGI SFIALRLFNV FGPRQDPNSP
YSGVISIFSK SIQAGLPITI YGDGTQTRDF IFVKDVAVAF TKALTTPLSV DSCIACNVGT
GQVTSLLELV HNLKIVTKSD SKIYFKNARP GDIEHSQADI SRIFSLLNFK PQWSFISGIH
NLVKSLAYKQ
//
