ID A0A0T9R2D3_9GAMM Unreviewed; 390 AA.
AC A0A0T9R2D3;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Multidrug resistance protein A {ECO:0000313|EMBL:CNI41184.1};
GN Name=emrA {ECO:0000313|EMBL:CNI41184.1};
GN ORFNames=ERS008529_03946 {ECO:0000313|EMBL:CNI41184.1};
OS Yersinia pekkanenii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=1288385 {ECO:0000313|EMBL:CNI41184.1, ECO:0000313|Proteomes:UP000045840};
RN [1] {ECO:0000313|Proteomes:UP000045840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A125KOH2 {ECO:0000313|Proteomes:UP000045840};
RG Pathogen Informatics;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CQAZ01000047; CNI41184.1; -; Genomic_DNA.
DR RefSeq; WP_049614805.1; NZ_CWJL01000032.1.
DR AlphaFoldDB; A0A0T9R2D3; -.
DR STRING; 1288385.ERS137968_04195; -.
DR OrthoDB; 9811754at2; -.
DR Proteomes; UP000045840; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR005694; MFP_proteobact.
DR NCBIfam; TIGR00998; 8a0101; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..347
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 206..289
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 390 AA; 42560 MW; 953881EA29551530 CRC64;
MSESAENQIA PPPQNKKKQR KHVLLLLTVI FIIIGVAYLI YWFLVLRHHQ ETDNAYVSGN
QVQIMSQVPG SVVSVNFENT DLVKSGDVLL TLDPTNAEQA YEQAKTTLAN SVRQTHQLMI
NSKQYQANIA LKKIELSKAQ NDLKRRVVLG SADAIGREEL QHARDAVEAG QASLDVAIAQ
YNANQALVLN TPLEKQPAVE QAAAKLRDAW LALQRTKVVS PITGFVSRRS VQVGAEIANG
APLMAVIPAN QMWIDANFKE TQLDNMRIGQ PATVVTDFYG DDVVFQGKVV GLDMGTGSAF
SLLPAQNATG NWIKVVQRLP VRIALDAKQL AEHPLRIGLS TTVRVDTINT DGQVLAQKVR
KDPAFVTNAL SLDLAPVNQM ISDIVHANAG
//
