ID A0A0U1A2C9_9MYCO Unreviewed; 163 AA.
AC A0A0U1A2C9;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856, ECO:0000256|PIRNR:PIRNR000194};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856, ECO:0000256|PIRNR:PIRNR000194};
GN Name=folA {ECO:0000313|EMBL:CPW71902.1};
GN ORFNames=D2E76_12365 {ECO:0000313|EMBL:RIT39522.1}, ERS075604_00121
GN {ECO:0000313|EMBL:CPW71902.1};
OS Mycobacteroides abscessus.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacteroides.
OX NCBI_TaxID=36809 {ECO:0000313|EMBL:RIT39522.1, ECO:0000313|Proteomes:UP000284557};
RN [1] {ECO:0000313|EMBL:CPW71902.1, ECO:0000313|Proteomes:UP000042347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PAP113 {ECO:0000313|EMBL:CPW71902.1,
RC ECO:0000313|Proteomes:UP000042347};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RIT39522.1, ECO:0000313|Proteomes:UP000284557}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G143 {ECO:0000313|EMBL:RIT39522.1,
RC ECO:0000313|Proteomes:UP000284557};
RA Ye M., Xu L., Zou Y., Li B., Guo Q., Zhang Y., Zhan M., Xu B., Yu F.,
RA Zhang Z., Chu H.;
RT "Linezolid Resistance in Mycobacterium abscessus: MIC Distribution and
RT Comprehensive Investigation of Resistance Mechanisms.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key enzyme in folate metabolism. Catalyzes an essential
CC reaction for de novo glycine and purine synthesis, and for DNA
CC precursor synthesis. {ECO:0000256|PIRNR:PIRNR000194}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate +
CC H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.5.1.3;
CC Evidence={ECO:0000256|PIRNR:PIRNR000194};
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903, ECO:0000256|PIRNR:PIRNR000194}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539, ECO:0000256|PIRNR:PIRNR000194,
CC ECO:0000256|RuleBase:RU004474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RIT39522.1}.
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DR EMBL; CSXT01000001; CPW71902.1; -; Genomic_DNA.
DR EMBL; QXBN01000008; RIT39522.1; -; Genomic_DNA.
DR RefSeq; WP_005057139.1; NZ_UGQJ01000002.1.
DR RefSeq; YP_001703821.1; NC_010397.1.
DR AlphaFoldDB; A0A0U1A2C9; -.
DR GeneID; 66968513; -.
DR OMA; RDNQLPW; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000042347; Unassembled WGS sequence.
DR Proteomes; UP000284557; Unassembled WGS sequence.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PIRSF; PIRSF000194; DHFR; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRNR:PIRNR000194};
KW One-carbon metabolism {ECO:0000256|PIRNR:PIRNR000194};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000194}.
FT DOMAIN 4..160
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 163 AA; 17647 MW; 1B8E52D96FB91717 CRC64;
MTGTIGLIWA QTRAGVIGAD GAIPWRLPED QARFKRITMG HTVIMGRKTW ESLPGSVRPL
PGRPNIVLTR DALFEPDGAL AVGCADAALA ASDEAPWVIG GGEIYRLFLP LAQRCEVTVV
EADVPGDALA PELGEGWVVE ENDWQTSESG LRYQFLSYRK VDG
//