UniProt: A0A0U1E6Z6

Database: UniProt
Entry: A0A0U1E6Z6_STACP

LinkDB:  A0A0U1E6Z6_STACP 
Original site:  A0A0U1E6Z6_STACP

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   EMBL (3)   
Protein domain (15)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (4)   
   SMART (1)   
All databases (24)   

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ID   A0A0U1E6Z6_STACP        Unreviewed;       453 AA.
AC   A0A0U1E6Z6;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Biotin carboxylase {ECO:0000313|EMBL:NMK97482.1, ECO:0000313|EMBL:VTR16189.1};
DE            EC=6.3.4.14 {ECO:0000313|EMBL:VTR16189.1};
GN   Name=accC {ECO:0000313|EMBL:VTR16189.1};
GN   ORFNames=EQ811_04920 {ECO:0000313|EMBL:TBW78421.1}, HHM13_05170
GN   {ECO:0000313|EMBL:NMK97482.1}, NCTC11045_01260
GN   {ECO:0000313|EMBL:VTR16189.1};
OS   Staphylococcus capitis.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=29388 {ECO:0000313|EMBL:VTR16189.1, ECO:0000313|Proteomes:UP000403553};
RN   [1] {ECO:0000313|EMBL:TBW78421.1, ECO:0000313|Proteomes:UP000291949}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H8 {ECO:0000313|EMBL:TBW78421.1,
RC   ECO:0000313|Proteomes:UP000291949};
RA   Williams M.R.;
RT   "Quorum sensing between bacterial species on the skin protects against
RT   epidermal injury in atopic dermatitis.";
RL   Sci. Transl. Med. 0:0-0(2019).
RN   [2] {ECO:0000313|EMBL:VTR16189.1, ECO:0000313|Proteomes:UP000403553}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11045 {ECO:0000313|EMBL:VTR16189.1,
RC   ECO:0000313|Proteomes:UP000403553};
RG   Pathogen Informatics;
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:NMK97482.1, ECO:0000313|Proteomes:UP000550736}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12-86 {ECO:0000313|EMBL:NMK97482.1,
RC   ECO:0000313|Proteomes:UP000550736};
RA   Ding L., Li P., Yang Y., Lin D., Xu X.;
RT   "The Epidemiology and Molecular Characteristics of Linezolid-Resistant
RT   Staphylococcus capitis in Huashan Hospital, Shanghai.";
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; JABBLX010000012; NMK97482.1; -; Genomic_DNA.
DR   EMBL; SCHC01000001; TBW78421.1; -; Genomic_DNA.
DR   EMBL; CABEEX010000003; VTR16189.1; -; Genomic_DNA.
DR   RefSeq; WP_002436565.1; NZ_WHVU01000001.1.
DR   AlphaFoldDB; A0A0U1E6Z6; -.
DR   GeneID; 77313554; -.
DR   eggNOG; COG0439; Bacteria.
DR   Proteomes; UP000291949; Unassembled WGS sequence.
DR   Proteomes; UP000403553; Unassembled WGS sequence.
DR   Proteomes; UP000550736; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR005481; BC-like_N.
DR   InterPro; IPR011764; Biotin_carboxylation_dom.
DR   InterPro; IPR005482; Biotin_COase_C.
DR   InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   PANTHER; PTHR45007; CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED; 1.
DR   PANTHER; PTHR45007:SF1; CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED; 1.
DR   Pfam; PF02785; Biotin_carb_C; 1.
DR   Pfam; PF00289; Biotin_carb_N; 1.
DR   Pfam; PF02786; CPSase_L_D2; 1.
DR   SMART; SM00878; Biotin_carb_C; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR   SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS50979; BC; 1.
DR   PROSITE; PS00866; CPSASE_1; 1.
DR   PROSITE; PS00867; CPSASE_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00409};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:VTR16189.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00409}.
FT   DOMAIN          1..444
FT                   /note="Biotin carboxylation"
FT                   /evidence="ECO:0000259|PROSITE:PS50979"
FT   DOMAIN          119..315
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
SQ   SEQUENCE   453 AA;  50515 MW;  765B2781F64B54BF CRC64;
     MYRCLIANRG EIAVRIIRAC REMKIETVAI YAKGDEDSLH VSLADQAICI GEANPLDSYL
     NIERIISAAE ITGANAIHPG YGFLSESTTF AEAVEENDIH FIGPNKKTME MMGDKITARQ
     TVHAANVPVI PGSDGEVESV DEIKKLAEEI GYPLVLKAAS GGGGKGIRIV KEPEQLEKSL
     KEAKSEGQKY FNDDRVYVEA FIPVAKHVEV QVIGDGKNNY VHLGERDCSV QRKNQKLIEE
     SPCAALTDER RERICNDAVK VAKASNYRSA GTIEFLVTED AHYFIEMNAR IQVEHTVTEM
     RADRDLLQAQ LYLLQYGELP FQQEDIVFNG HVIEARINAE NPEKKFQPTP GKVKKLHLPQ
     GFNIRVDSLL YSGYQVSPYY DSLVAKVIVK DSNRQTAINK LKVALDEMVI EGFTTTADFL
     YAVLSYPLYA DGDASEVDIK FLEKHQIIKG VDL
//

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