GenomeNet

Database: UniProt
Entry: A0A0U1KW05_9FIRM
LinkDB: A0A0U1KW05_9FIRM
Original site: A0A0U1KW05_9FIRM 
ID   A0A0U1KW05_9FIRM        Unreviewed;       400 AA.
AC   A0A0U1KW05;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Dihydropteroate synthase {ECO:0000256|ARBA:ARBA00016919};
DE            EC=2.5.1.15 {ECO:0000256|ARBA:ARBA00012458};
DE   AltName: Full=Dihydropteroate pyrophosphorylase {ECO:0000256|ARBA:ARBA00030193};
GN   ORFNames=SpAn4DRAFT_3970 {ECO:0000313|EMBL:CQR71465.1};
OS   Sporomusa ovata.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Sporomusa.
OX   NCBI_TaxID=2378 {ECO:0000313|EMBL:CQR71465.1, ECO:0000313|Proteomes:UP000049855};
RN   [1] {ECO:0000313|Proteomes:UP000049855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Nijsse Bart;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate =
CC         7,8-dihydropteroate + diphosphate; Xref=Rhea:RHEA:19949,
CC         ChEBI:CHEBI:17836, ChEBI:CHEBI:17839, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:72950; EC=2.5.1.15;
CC         Evidence={ECO:0000256|ARBA:ARBA00000012};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-
CC       dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-
CC       dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00004763}.
CC   -!- SIMILARITY: Belongs to the DHPS family.
CC       {ECO:0000256|ARBA:ARBA00009503}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CTRP01000004; CQR71465.1; -; Genomic_DNA.
DR   RefSeq; WP_021167561.1; NZ_CTRP01000004.1.
DR   AlphaFoldDB; A0A0U1KW05; -.
DR   UniPathway; UPA00077; UER00156.
DR   Proteomes; UP000049855; Unassembled WGS sequence.
DR   GO; GO:0004156; F:dihydropteroate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00739; DHPS; 1.
DR   Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR   InterPro; IPR045031; DHP_synth.
DR   InterPro; IPR006390; DHP_synth_dom.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR000489; Pterin-binding_dom.
DR   NCBIfam; TIGR01496; DHPS; 1.
DR   PANTHER; PTHR20941; FOLATE SYNTHESIS PROTEINS; 1.
DR   PANTHER; PTHR20941:SF1; FOLIC ACID SYNTHESIS PROTEIN FOL1; 1.
DR   Pfam; PF00809; Pterin_bind; 1.
DR   SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR   PROSITE; PS00792; DHPS_1; 1.
DR   PROSITE; PS00793; DHPS_2; 1.
DR   PROSITE; PS50972; PTERIN_BINDING; 1.
PE   3: Inferred from homology;
KW   Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000049855};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CQR71465.1}.
FT   DOMAIN          141..389
FT                   /note="Pterin-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50972"
SQ   SEQUENCE   400 AA;  44025 MW;  442278B2F98E589A CRC64;
     MQYNMRIIEI KNREQAQKEV AMVNCDPAGA AIMSNKAVYK TIKVENVVSK AALILKQTFL
     SKGGEASVSR GAADYSSQYT DVLLSGSLKH FKQCIPQLKV QPWGLKKLAE ELEAIIAVDE
     KFPQRSYKLG AHTLSVSPEK TLIMGILNIT PDSFSDGGKF NNIDVALKHV EQMIKEGADI
     IDIGAESTRP YGSHKISAEE ELERLMPILE KVLDTFSIPI SIDTYKASVA RETLKAGAHI
     INDIWGLQFD PEMAKVAAEY NVPVVIMYNQ GEAEYQRDIM SHMLEFLRRS MQIGETAGIR
     PDNFIVDPGI GFVKKGSDNL VIMARLDELK SLGCPVLLGT SRKRFIGDIL DAPANDRVEG
     TAATVALGIT KGANIVRVHD VKAIARVARM TDAMLNAKYK
//
DBGET integrated database retrieval system