ID A0A0U1L1L4_9FIRM Unreviewed; 212 AA.
AC A0A0U1L1L4;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase {ECO:0000313|EMBL:CQR73053.1};
DE EC=2.1.1.13 {ECO:0000313|EMBL:CQR73053.1};
GN ORFNames=SpAn4DRAFT_2285 {ECO:0000313|EMBL:CQR73053.1};
OS Sporomusa ovata.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC Sporomusa.
OX NCBI_TaxID=2378 {ECO:0000313|EMBL:CQR73053.1, ECO:0000313|Proteomes:UP000049855};
RN [1] {ECO:0000313|Proteomes:UP000049855}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Nijsse Bart;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CTRP01000012; CQR73053.1; -; Genomic_DNA.
DR RefSeq; WP_021167863.1; NZ_CTRP01000012.1.
DR AlphaFoldDB; A0A0U1L1L4; -.
DR Proteomes; UP000049855; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008705; F:methionine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02070; corrinoid_protein_B12-BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR036594; Meth_synthase_dom.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR SMART; SM01018; B12-binding_2; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF47644; Methionine synthase domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51337; B12_BINDING_NTER; 1.
PE 4: Predicted;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:CQR73053.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000049855};
KW Transferase {ECO:0000313|EMBL:CQR73053.1}.
FT DOMAIN 1..88
FT /note="B12-binding N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51337"
FT DOMAIN 88..212
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 212 AA; 22323 MW; A732A9837F261500 CRC64;
MSNFEKLAEA VYQGDDSEVK TITQGMIASG VSPMEIVSKG LLAGMDIVAP KFKAGEMFIP
EVMMSAKALS EGLTIVKPLL SAEDSANVST FVMGTVKGDL HDIGKNLVVM LLESGGFNVV
DLGVDVAPET FVAAIKEHKP QIVGMCALLT TTMMAMQDTI DAITEAGLRD KVKVLVGGAP
LYPEFADKIG ADGYCVDAVA CKEMAAKMVV NK
//
