ID   A0A0U1L447_9FIRM        Unreviewed;       256 AA.
AC   A0A0U1L447;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000256|ARBA:ARBA00018080};
DE            EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
GN   ORFNames=SpAn4DRAFT_0747 {ECO:0000313|EMBL:CQR74285.1};
OS   Sporomusa ovata.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Sporomusa.
OX   NCBI_TaxID=2378 {ECO:0000313|EMBL:CQR74285.1, ECO:0000313|Proteomes:UP000049855};
RN   [1] {ECO:0000313|Proteomes:UP000049855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Nijsse Bart;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001633};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
CC   -!- SIMILARITY: Belongs to the TrpC family.
CC       {ECO:0000256|ARBA:ARBA00008737}.
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DR   EMBL; CTRP01000014; CQR74285.1; -; Genomic_DNA.
DR   RefSeq; WP_021170289.1; NZ_CTRP01000014.1.
DR   AlphaFoldDB; A0A0U1L447; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000049855; Unassembled WGS sequence.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CQR74285.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000049855};
KW   Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT   DOMAIN          2..250
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /evidence="ECO:0000259|Pfam:PF00218"
SQ   SEQUENCE   256 AA;  27469 MW;  BD2EFCF579DFA5B5 CRC64;
     MLDKIVMQTR LAVAAAKMDE PLAKIENQVV AGSFAFSRAI KEAAWAVIAE CKLVSPAKGT
     LCNTYTVLEL AQIYAGNGAT AVSVHTNTAF DGHINDIVKV KAAVKLPVLC KEFIIDEYQL
     YTARAAGADA VLLIAAIVSD AELVRFLQIA RELGMDCLVE VHTLAELIRV QQTDARLIGI
     NNRDLQTFTT TISQTFTLLK HCEPDRVIIS ESGIKNGEDA QKLKTAGVKG ILVGESLVIA
     SDVAAMTREL ALSGSK
//