ID A0A0U1LW68_TALIS Unreviewed; 2331 AA.
AC A0A0U1LW68;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Cu2+-exporting ATPase {ECO:0000313|EMBL:CRG87654.1};
GN ORFNames=PISL3812_04674 {ECO:0000313|EMBL:CRG87654.1};
OS Talaromyces islandicus (Penicillium islandicum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Islandici.
OX NCBI_TaxID=28573 {ECO:0000313|EMBL:CRG87654.1, ECO:0000313|Proteomes:UP000054383};
RN [1] {ECO:0000313|EMBL:CRG87654.1, ECO:0000313|Proteomes:UP000054383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WF-38-12 {ECO:0000313|EMBL:CRG87654.1};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CVMT01000003; CRG87654.1; -; Genomic_DNA.
DR STRING; 28573.A0A0U1LW68; -.
DR OrthoDB; 5480493at2759; -.
DR Proteomes; UP000054383; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR46594; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR46594:SF4; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054383};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1640..1661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1667..1685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1706..1728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1889..1915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1927..1954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2237..2256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 247..557
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 608..727
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 827..1074
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1490..1556
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 1073..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2331 AA; 253109 MW; 46891C7640302DE8 CRC64;
MHNNCPQTAD QVFGPAVSCP HVFDFTLLFE QSIFSIGPSV LFLLLLPLRV WNLHGKTIKT
TKLGNNALWL KLTLAGSLIG IQIATLTLWA QDNTVRTAIP SAILSLLDAL LITILSVIEH
SRSVRPSTLI CLYLLISIPL DSVQVRTLFL RSNYPSALAG TLAAAVGLKV FLLSIEIQRK
ERYLSDRHRY PPEELSGIFS RTVFSWLTEL FLKGFRKILT LDDLFPTDNE LDSNLLMGGL
KVKWAKYKSS NPLSIIYATV SCLRWALLRV VVPRLCLIGF SYAQTFFIER AITLLHEPAT
QDSKNDGYGL IGAAALIYGG IAISTVHYQH QLFRMITMFR GAFVALIYDY SMTLREGQYN
ESAAITHMST DVDMIARSLE QANELWARIL EISIGIWLLE RQLGAVCIAP VLVIIGCNDL
RRYREVLHAC ALEDDLATMS NGDESLVGSQ GIILSGGQKQ RLALARALYS KKQFLVLDNA
LSAVDHHTEH IILERVFGGR GLCRDSGMSV LMTTHSKKYL GLAHEILVLN AQGHVVKQGP
FVPSLLADQV TEFGESDTSE SLDRDSSITQ KAVTVPKTLT PEIISDMSRQ TGDIAVYSYY
LRAIGWRLVL GACLIILVYT FSANFPQVWL DIFTNDNGGQ PGRFIGIHVL LMVAASGSQG
LMIWQIMINI VVRSGLALHG ILVRAVMNAP MQVFAEVDSG VILNRFSQDM TLVDAVLPTV
TFGTFLGKYA SRSGYGYTFL YGFKLVSVFI ANSGCTISTD PGKLGVSLTA IMAFNQSLQE
LVTSWTAMET SLGAISRTRS FELNTANEHL SGENFVPPPE WPSHGKVELR SVYASYDGTR
DVLDNINITI EAGERIGICG RTGSGKSTLL SLLLRLIDHK AGTIRIDDID IATIPRNILR
SRLIAVPQDP LPALPGYSIR HNIDPNENAT DTMILGAIKK VGLLELVESR GGLYGEDFSS
QPLSQGEQKL FALARALISK WTRDSATGGL GGVLILDEFT GGTDAETERS MLKIIEEEFS
GYTIIQITHQ IDAITSMMDY DYHGLLASAP EPDFIPEEKS NCKDGCCDGS DAEPLNTTAP
GHEEPAQEHS DDGCSPGNCS DDKIENDIDA PDCCRGKPRP CCDTSCLDRL AMRECAMSAA
ATPGLNTCGE ATVDKPCSQH SLSALDRYGA TLQALGCICR TLIALGQEAC CELRERPVLD
KKQCSSSRSS SSRSLNRTSL DLCSGSVTKH QAAQNRLCPP RGSSESIIFT NKSSVDASVV
SSCSKDKPAK CSKPYYSDGT PAEEPRLRSN CAASCCEDDN TFKEVPSKNK RSCSCCSEDT
PAKDNCAKSM SALGKPAKQP VAQIGCVGSC CSESPHVEEQ PPEAGCPRNQ RVSDNDTKSI
YTDSYCSKVK PVVELPTSGC AGSCCGKAKN MITTTESSKA ASSGHCYKPP KQDVLKTPKT
SCAKPCCTEQ QPVSPQGSCA DACCSFAVPN PEKVPIQPTT DVENQGTGKE HVVLSISGMT
CTGCETKLNR TLVTVPAVKD LKTSLVLSRA EFTIDLSLST VEEVIKYLER TTEFKYERVQ
NQGSSLDIII PDEPSKFISQ TWPDGVIDMS PIDKQTVRVA FDPKIVGARD LTEKIWRPSI
ELAPHGDPSL KAGSKHVRHV GYMTLLSAIL TIPVLVMAWA PLPKREVTYS SASLTLATII
QVVIAGPFYP KALKALIFSR VIEMDLLIVL STSAAYIFSV VSFGYLIAGK SLSTGQFFET
STLLVTLIML GRWIAALARQ RAVESISIRS LQASAAILID KESGTEREID ARLLQYGDTF
KVLPDTRIPT DGTVIHGSSE VDESMLTGES RPVEKYPMSV VIAGSINGPG VIIVRLNRLP
SDNTINTIAA MVDEAKLSKP KLQALADRVA SYFVPVVVTL TIITFVIWVA VGMTIRGYDG
SKATTQAITY AITVLIVSCP CAIGLAVPMV IVIASGSAAE RGIIFKSADA IEVAHKTSHV
VFDKTGTLTR GKLSVVAKDY VDEDKLPLLL GLIENSRHPV SVSVAAHLKD TGVVAATVPE
PKSLAGKGIE TTLDGRRLRA GNSRWLGLLE HELVQPMLDQ GYTVFCFTID DVVQAVYGLE
DELRPDAAAT INTLQKRGIS VHMVSGDDDG AVQILASKLN IPGDNVRSRS SPADKKRYIQ
TLLGTGADHK KPVVVFCGDG TNDAVALAQA TIGVHINEGT DVAQSAADVV LMRPFLAGIP
SMMNASQNSI NRIKLNFIWS FVYNTFAILL AAGAFVNVRI PPEFAGLGEL LNYYNLNLNW
NAWIQIDPIS TRSSNNLGGS WRSGDQYISR PKSIQNFLPS SQETLFQSKI F
//
