ID A0A0U1LX31_TALIS Unreviewed; 402 AA.
AC A0A0U1LX31;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Sterigmatocystin 8-O-methyltransferase {ECO:0000313|EMBL:CRG87949.1};
GN ORFNames=PISL3812_04971 {ECO:0000313|EMBL:CRG87949.1};
OS Talaromyces islandicus (Penicillium islandicum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Islandici.
OX NCBI_TaxID=28573 {ECO:0000313|EMBL:CRG87949.1, ECO:0000313|Proteomes:UP000054383};
RN [1] {ECO:0000313|EMBL:CRG87949.1, ECO:0000313|Proteomes:UP000054383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WF-38-12 {ECO:0000313|EMBL:CRG87949.1};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CVMT01000004; CRG87949.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0U1LX31; -.
DR OMA; LIYWIRR; -.
DR OrthoDB; 1067404at2759; -.
DR Proteomes; UP000054383; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CRG87949.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054383};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:CRG87949.1}.
FT DOMAIN 174..378
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 310
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 402 AA; 44693 MW; 7F5289F95E3F8AFA CRC64;
MASQLDSLID QLGQTAKAIQ NDPSYFQSSP EQRLKLLKAT QELYKTTQDP MEAYMEFLIS
MARVTVIRLF IKWKVFEIIA TEGTISYASL AEKANADATL ITRLARMLVC TGILQQNTAD
ELSLSPSANI FIAPHPASAL VQFGYDFHCV AAMAMPKYFD IYGRKEPVGR YKTITAYAYG
NPDWTVWEHL NSDPAGMAVF MTSMVAMSHM QPIVGSYDFK WLLDEAPKSE DRTLVVDIGG
GKGHAIQAIA QATPGLPLSR CVVEDLDDII QEAKINASSE MSQVQFVVMD FHKEQPVKDA
LIYYIRRCLH DYGDDEVTGI LEQTRKSMAK DSKLLIVEQI LDNPPDPFAV AADVFISTIG
GKERTMEDFE HVTSRAGLKI VKVHRSPGSD VGIIECEKDT SD
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