UniProt: A0A0U1LXS9

Database: UniProt
Entry: A0A0U1LXS9_TALIS

LinkDB:  A0A0U1LXS9_TALIS 
Original site:  A0A0U1LXS9_TALIS

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Ontology (6)   
   GO (6)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (39)   
   InterPro (22)   
   Pfam (8)   
   PROSITE (3)   
   SMART (6)   
All databases (46)   

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ID   A0A0U1LXS9_TALIS        Unreviewed;      2422 AA.
AC   A0A0U1LXS9;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Lovastatin nonaketide synthase {ECO:0000313|EMBL:CRG87892.1};
GN   ORFNames=PISL3812_04913 {ECO:0000313|EMBL:CRG87892.1};
OS   Talaromyces islandicus (Penicillium islandicum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Islandici.
OX   NCBI_TaxID=28573 {ECO:0000313|EMBL:CRG87892.1, ECO:0000313|Proteomes:UP000054383};
RN   [1] {ECO:0000313|EMBL:CRG87892.1, ECO:0000313|Proteomes:UP000054383}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WF-38-12 {ECO:0000313|EMBL:CRG87892.1};
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CVMT01000004; CRG87892.1; -; Genomic_DNA.
DR   STRING; 28573.A0A0U1LXS9; -.
DR   OMA; TESHTHY; -.
DR   OrthoDB; 5396558at2759; -.
DR   Proteomes; UP000054383; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05274; KR_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF22; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054383};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          6..431
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2346..2422
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2422 AA;  266562 MW;  30DF28B0A76F9D3B CRC64;
     MIDMSSCPIA VVGLACRLPG SATDGDKLWD MLSKGKNVWS EVPTSRFNEK SFYHPHPEHD
     GTTNHQGGHF LEEDVSLFDA TFFGISPAEA ESIDPQQRLL LEIAYEALEN AGHSLETVRG
     SDTAIYTAMF TRDYALHLAK DPLNMPKYGT TGTGDAIIAN RVSYIFDLKG PSISMDTGCS
     GSLVAINQAC QALRAGETSM ALASGVSIIL QPDHMFGMSN LHMLNENGRS YPFDERGDGY
     GRGEGVATVV LKRLTDAIAA GDRIRAVIRG SGVNQDGKTS GLTMPNRHAQ ELLIRDVYSR
     AGIDPQTVQY VEAHGTGTRV GDEMELSALA ATFGDNGRRS DEFFVGSIKS NIGHLESASG
     IAGLIKVILM LERGYILPNA DFKTPKSNIN LERSKIRVPT KLTQWSRSGI RRASVNSFGY
     GGTNAHVILE EADPTLAMAN GIAPSTQILL NGLPCEARNG LFRDAPNGHG LVNGHRNVIE
     NGNGSLWSDK CRHRLFPISA QTKDGVFSII RNLKTWAQAQ DVQLDDETLD HLSYTLTKRR
     STLRWRYSLV ADSAQALISS LRSPENIKPI QASVKTNIGF VFTGQGAQHF SMGRELIMKS
     TPFTQSLYQS EKILKNLGAN WSLLGELMRD ENTTRLNETA LSQPVTTAVQ IALVDLLFAI
     QIQPHMVVGH SSGEIAAAYA AGSISRSTAL TVAYYRGLIP QFCKNAALSK GGMLVVSQSE
     EEILPVLEQL KDGKASVACL NSPSSTTISG DYKAICELET VLEELNVTNK KVKVDIAYHS
     HHMAAVANEY RRSLANVADA SPKNSVTFIS SVTASPKNHG FCADYWVDNL VSKVQFYKAL
     EHYCVSQLGN TSQSSANTQP MHNIFIEIGP HSALARPISH TVAEKAPSLN FSYSPTLVRG
     RDAEQSIFEL VGKLSDQGVK FNKSIVSTFM EQRHMAKTLS NLPPYPWNHT NVYWHESRLS
     KEYRFRPHAE HDLLGVRIPG TSMPIWRHII STEKLPWLAD HIIDGLVVFP GSGYLCMAIE
     AVKQLYPEAG KSAITLTDIA FEKALIIPKT TGKIEMQLIL QNKRATEFQM YEFHILALTE
     HETWREHCSG KIKVRSQNGN SRNAKGLSYC DFTETNCEHL DTMLYHGTGR KMDSEAVYQQ
     LSRDGNQYGP CFATIKEAIV DKDRAITLLT IPNIRSVMPN KFMQPHTIHP STLDVILHGA
     LLIKESTTLP GPVMPVSIGE IRIEPSIVDE ASQSLLVDLH VSKLGLDLST ANMSVFLGSK
     KDGSKSHKPK PLVTISGAEL RKIQGNFQQS GLIENNNLDM AYTMKWIPDI NFFNEPSTNF
     LRSFARQLFL KYAHLNIIEV NSGSGQWTKS ILESFKGDET FVRSYHATDS SLSYDETRAK
     LSEWATVLHY KTLDISQSPA KQGFNPGTFD LVVMNLASSL SDIDSVSLTN LRSLLRVGGR
     LMILTNNNTS EDHDHLSSLL IQYSFSEAGV FIDTPAGFVD PVSIIVSKAI TTPIQTVGKS
     SFKIIAPTNE QHLSQAIQYY LTRKGHDVSI TSWKNLCQEN VQQKVYIILD DTGNPVLMNS
     TNEIFRKLID LVQNEMKIFW ISYQGYNSGG SYTAASNGLV DGLVRTARAE YPSLKFVTLH
     VRDSIQAAIP VLTESVGKII ETSIINPGCD DRLCEEEFVY HNNEILIPRV LRSVTLNPPA
     SQTDTIKIAY GNPGKLTKLA KSQSPSKTQA SHFDTAPFTS PILAEDELTI DVKAHSLTPD
     HLLNLEQSIF QLDAKATYEI AGTVGTIGIK STSGDYRFKP GDRVCGWVFD SSAYASSYCV
     KVGNIVPLPD NIPIEIGTAL PFTFITAYYS LVVIANLQEG QSLLISGPVT NITRVIAKMA
     CKLGASVFAT FSTEDEQKDL VRRAGIPSEN VFCEDQISTF NPANINFNLV ITSSGDTDAD
     ISMQNFVAES GIYILLEKSS GHRRSRGVPT PRRIDIMIVS LNPHKVMRSI ISRTPDILEK
     AFLLLGREIS QSLIDASIYP IGDIDNAISD ISSPKSNERA ILKIDDNSMV QATRNRYDPD
     WKFDTDSTYV IVGGFGDVGR QICNLLAYRG AKHILILSRQ TPSFEKRLNL QSELQKKSPG
     LIVHSFSCDI SAGTAIEQIR TYIDTHSEIP PVRGVIQSAA ILADSTLENM TAEKFRIPLQ
     SKYYGTLNLL SSFNDVSLDF FMMVSSVTGV LGSRGQSNYV AGNAFLDAIA QELTESHTHY
     ISLDIGLVDG SSAYDDLTGR IRRQNLMRQG MPPITAAELD TFISYALSPQ AREDQCRQAL
     LGFNGRSIAE ASEPPTTSWS PMFVHVRGEV HNKEEEEEDG ISANAETPRS IKERLQDLAG
     SKDYVEGAKQ LIVLAIKEGL GKLVAMEPSE IDEYTPLLDY GLDSLAAVDL RNWLKREIEA
     SIRVTEILDA ENILSLAIKI AE
//

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