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Database: UniProt
Entry: A0A0U1M2Y9_TALIS
LinkDB: A0A0U1M2Y9_TALIS
Original site: A0A0U1M2Y9_TALIS 
ID   A0A0U1M2Y9_TALIS        Unreviewed;       604 AA.
AC   A0A0U1M2Y9;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   10-APR-2019, entry version 17.
DE   SubName: Full=Tripeptidyl-peptidase I {ECO:0000313|EMBL:CRG89939.1};
GN   ORFNames=PISL3812_06978 {ECO:0000313|EMBL:CRG89939.1};
OS   Talaromyces islandicus (Penicillium islandicum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces.
OX   NCBI_TaxID=28573 {ECO:0000313|EMBL:CRG89939.1, ECO:0000313|Proteomes:UP000054383};
RN   [1] {ECO:0000313|EMBL:CRG89939.1, ECO:0000313|Proteomes:UP000054383}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WF-38-12 {ECO:0000313|EMBL:CRG89939.1};
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
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DR   EMBL; CVMT01000007; CRG89939.1; -; Genomic_DNA.
DR   EnsemblFungi; CRG89939; CRG89939; PISL3812_06978.
DR   OrthoDB; 1294880at2759; -.
DR   Proteomes; UP000054383; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054383};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054383};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    604       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5018030050.
FT   DOMAIN      210    604       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    285    285       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    289    289       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    504    504       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       546    546       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       547    547       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       582    582       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       584    584       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   604 AA;  64005 MW;  8E0D170B2F0BEA4B CRC64;
     MARNILLGAG LLAQLAAPVL GAAALTTHES LISLPHGWSH DNQPESDAPI QLSIALTLQN
     IDQLESKLKS VSTPGGASYG QYLDESEITS QFGPSDASVE AVTNWLKEAG ISAIHTTDHS
     INFATTVGKA NSLLGANFKY YTNGEISKLR TLAYSIPSDL KSDIDLISPT TFFGKTTAQR
     SIQTFKSKRA TSTTSSASSS VSVAASCQTS ITPACLKEMY SVGNYTPSVE HGSRVGFGSF
     LNESALYSDL ALYEKLNKIP SQNFTKVIIA NASNSQDPAS GGYGESNLDV QNIIGISHPL
     PVTEFLTGGS PPYVPSLDDT TNTNEPYLPY YEYLLSQSTE SLPQVISNSY GDDEQSVPFQ
     YAVRTCSLIG LMGLRGITVL ESSGDLGVGS GCLSNDGKNK TQFEPIFPAT CPYVLSVGGT
     VSVTPEEAWS ASSGGFSNYF PRAWYQEVAV ESYLRHEISP ATKKYYESYT NFAGRGFPDV
     SAHSLTPDYQ VIYAGKPAGS GGTSAAAPVF AGIIALLNDA RLAAGKPALG FLNPFFYFLG
     YKGLNDITLG QAVGCNGING QSGEPVPGGG IIPWATWNAT EGWDPVTGLG TPNFQKLKEI
     VLSL
//
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