ID A0A0U1M791_TALIS Unreviewed; 506 AA.
AC A0A0U1M791;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Proline dehydrogenase {ECO:0000256|ARBA:ARBA00012695, ECO:0000256|RuleBase:RU364054};
DE EC=1.5.5.2 {ECO:0000256|ARBA:ARBA00012695, ECO:0000256|RuleBase:RU364054};
GN ORFNames=PISL3812_07821 {ECO:0000313|EMBL:CRG90776.1};
OS Talaromyces islandicus (Penicillium islandicum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Islandici.
OX NCBI_TaxID=28573 {ECO:0000313|EMBL:CRG90776.1, ECO:0000313|Proteomes:UP000054383};
RN [1] {ECO:0000313|EMBL:CRG90776.1, ECO:0000313|Proteomes:UP000054383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WF-38-12 {ECO:0000313|EMBL:CRG90776.1};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC {ECO:0000256|RuleBase:RU364054}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC ChEBI:CHEBI:132124; EC=1.5.5.2;
CC Evidence={ECO:0000256|RuleBase:RU364054};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|RuleBase:RU364054};
CC -!- SIMILARITY: Belongs to the proline oxidase family.
CC {ECO:0000256|ARBA:ARBA00005869, ECO:0000256|RuleBase:RU364054}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CVMT01000008; CRG90776.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0U1M791; -.
DR STRING; 28573.A0A0U1M791; -.
DR OMA; QECMGFL; -.
DR OrthoDB; 7218at2759; -.
DR Proteomes; UP000054383; Unassembled WGS sequence.
DR GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR002872; Proline_DH_dom.
DR InterPro; IPR015659; Proline_oxidase.
DR PANTHER; PTHR13914:SF30; PROLINE DEHYDROGENASE; 1.
DR PANTHER; PTHR13914; PROLINE OXIDASE; 1.
DR Pfam; PF01619; Pro_dh; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU364054};
KW Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU364054};
KW Proline metabolism {ECO:0000256|ARBA:ARBA00023062,
KW ECO:0000256|RuleBase:RU364054};
KW Reference proteome {ECO:0000313|Proteomes:UP000054383}.
FT DOMAIN 181..484
FT /note="Proline dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF01619"
SQ SEQUENCE 506 AA; 55735 MW; CD7C16D136EB3039 CRC64;
MNPTRSARVF SRPASYHILQ ARYVSTTKTT KSSAVVSAAP PTAAAAAAAA DTSVTTTSAL
QRALPQHIGD LIGTSKPNAD SASPLAKLPL SSVLRSLVIL SFSSSHLLLK PCIYTLSALA
NPKTPLTDTD RNPLLHWLIK NTIYKQFNAG ENKAEVQRSI AEIKNLGCRG VLLGYAREVL
TGESKASPHD AKVAKQDVDA WLQGTLQGVE MATEGDFVAL KFTGMGTQAV HLLQNNLPPT
DYMDAAIRKA CDATIAKGTR LLVDAEEQAV QPGIENWVMK YQKYCNLQTP GKATIYCTYQ
AYLKSTPATI AKHLAMAERD GYTLGVKLVR GAYMKIEPRH LIWDTKEDTD TCYDGVVDAI
LTRRYNSMLS PAPESVAKEM MPPVNLIIAT HNRESVQKAH SIRLRQVQNN EPRIDLSYAQ
LQGMADEVSC DLINGFQDAA RQHPHQILES PNVYKLLTWG SVQECMGFLL RRALENTEAV
SRTKESQKAM IQELWRRIKT VFVRGN
//
