ID A0A0U1MB92_TALIS Unreviewed; 2604 AA.
AC A0A0U1MB92;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Putative polyketide synthase 1 {ECO:0000313|EMBL:CRG92280.1};
GN ORFNames=PISL3812_09337 {ECO:0000313|EMBL:CRG92280.1};
OS Talaromyces islandicus (Penicillium islandicum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Islandici.
OX NCBI_TaxID=28573 {ECO:0000313|EMBL:CRG92280.1, ECO:0000313|Proteomes:UP000054383};
RN [1] {ECO:0000313|EMBL:CRG92280.1, ECO:0000313|Proteomes:UP000054383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WF-38-12 {ECO:0000313|EMBL:CRG92280.1};
RA Syromyatnikov M.Y., Popov V.N.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CVMT01000012; CRG92280.1; -; Genomic_DNA.
DR STRING; 28573.A0A0U1MB92; -.
DR OMA; GITAYEM; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000054383; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054383};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..426
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2517..2595
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2604 AA; 285193 MW; 507CDC4468DA2C70 CRC64;
MDSFAIVGIA FNLAQDVDNE DRLWEVIETR SNLATEWPAD RANFETYHND GSSQVGTLHA
RGAHFSHADW TAFDAPFFFI TPHEAATMDP QQRWALQTVY HAFENAGIPM ESLRGSRTAV
FGSCSDDFPR SMTRDLDAAP RLTLTGTDPS VLVGKVSWFF DLAGPCLNIN TACSSSLIAL
DYACKAMQAG DASAAVVLGS NFMLNPDAST ILSNLSFLSP DSVCYSFDGR ANGYARGEGI
LAMVVKPVEN AIRDGDVIRA VIRATGANQD GRTPSLTQPN PDAQESLIRH VYQKAGLGFS
QTRYVEAHGT GTPTGDPIEA TAIGRVFGEH RSAQDPILIG SIKGNIGHVE AGSGLAGTLR
AVLAVEKGLI PPQALFKAMN PAINSDLYNL DVPVSCVPWP KPFGVRRASV NSFSLGGSNA
HIVLDDALSY LNNRGLHGYH NCTMYADGLG ENTFINGTTY SSSESITNIS TTLYTKEINT
KGINTKEARL LVWSGADPGA IDRFAHVYKS YLKRKVGRSH RKLNQLAYTL SNRRSRLQWR
SFAIASADNI ISDDGTVCLA MTKPTRLPTE KSVAAFVFTG QGAQYASMGI GLLSYKVFAD
TLQRIDSIFS SFGSTWKLVD VLQDDQLLHS PQFSQPLCTA VQIAIVELLR SVHVTPCAVM
GHSSGEIAAA YTAGALSLES ACKVAYYRGV VSEKLKSATA TPGSMISVNL ERASVYEYLQ
SMGIDNIPLT VHVACVNSPT NCTLSGDEHL IDLIKDKMDE DQIFARKLNT GVAYHSPAMK
TVAAEYVELL GQLNPGTGAG RGQTTIASSV TGRLVTDPSC FSSAQYWVDN LISPVLFTDA
LQSFAVKGGS DLGLQNNQSI TDYIEVGPDA ALRRPIKDTL EAIGTSGSTH KGSAEATELK
SITSARYHSV LHRSKQPIDS LLSLLGNLFC VGYPVSIELA NHHDANAFPP PLVDCPRYPF
DLTKKYWYEG RINKDTRLRP HAKGVMIGKR SPNWNQLRPS FRNWLGVDAM PWLEEHCISG
KVVCPGMGMI VMTLEGLRHL VEMNAKTTSA PISGFQFQEA HFLKPIPVPE DSRQNTEVSL
CLRPKQEVYE KDISWWEAAL FAHNGSNWTE CFQAVVQVHL EQNSTEVDGG RERREETAKY
RKFQDEATDS CDKAVDSEAF YQYLRHYGMA YGPSFSVLRD ISWNGLATSQ ATIPQDLMLD
SGEASPMHPA VLDAAIQLPL AQISKGLSIP LDTYVPQDLY GLWMSAKTWK VPDSSVVITT
AVDFSRPSAL EASISVFNED GTMILSLERG LLASVSSNDE PKLGEEQPRL IYKMERLPLL
SQLTSADLQV ACEPESYQQS EMEKSWSDRL EAALISSAQD ALYRLYSSGF DITSAPAHLQ
TFINVLQRNY GPNSNHRKEF IDQELAKCLE YSPSWGLYTQ AGRFLEPLLR SEADPLELLV
SSEVADRSYA LLFDNAADDR LFRFLELASH ENPGLRILEI GSGTGGLTTH ALSHLEQLEK
RVGSMRFSRY VFTDISPAFF EAGKTKFARF GDRLDFQKLD IEKAIDTQGF ALESFDLVLA
GCVLHATANI AESMGNVRKL LRQGGHFVAL EITQTNLARS LVGFGSLPGW WLSTEDWRRN
GPLMSKETWD RVMKQTGFSG IEATWDDGEG GCMMITHAME ATAVSISEPL EQLGFGNKRT
LTIVVLDSCS ELQQTIADRI HQWSGLGSRI IPLGDVGAVE WKEDDVVLSL IELGEPLLAA
PTREAFENIR TMLKNTQNLL WVALPNPSSP PSSTGAVDPR FDLALGFLRT IRYEEPSKGI
VTLSCCNRAT LSEANVVRFI KDILCQCFRP QNPSRENEFV IEKDTLCVDR LIYDTDQEED
RLARIFPSLQ PGQTLGNAPP TILSPGSPGM LNTLRLVETE TPVQMAPQTV EIECRAWPVS
FRDVLIALDR YGDQSDTSGM GWELAGVVSR VGPGVSEFKP GDRVCTGEVA GMRSHVQARQ
DMVFKIPDDM SFARSVAALN PLMTAHHGLV NVARLKKGET ILIHAAAGST GQMAVCIAQR
IGAEVYATVG FDDKKKLLME EFGIPESNIF YSRDTSFKLG ILRETAGRGV DVVLNSLSGD
KLKASWSCIA PFGRFIEIGK ADIGAGSSLP MSHFAKNATF SAVDLAHLGA EDPDALRDLT
RTAVDMLFHT NVGRYPKPVH LFPVAESEKA FRFIQSGKNT GRTIITLDPE DTVSKFMIKR
AGWRFPKSAT YIIVGGLGGI GRSLISWMFE RGARYFMTPT RSGIKSEAVS SFVHSLERQG
AVIITTPCDA SSRDELARLL DKHRDLPPIR GCINAAMSLQ DSTYFNMTHA QWQRSLQSKV
DSSWNLHQLL PEDLDFFILL SSVSAVYGSP GQCNYAAACS AQDALARHRI AIGRRAVSLN
LALIRDVGAM VDHDDFKLSA NTIRDAKKVF CRDILAVLDR YCDPLNLARR DNDVQIIVGG
VSPSDWKTAH LLPSHIEGRP FFSGFPVATK QDALSHRGGR STNESALLFR RATSSSAKRS
VALEAIVHKL ADALCISKED VDGRNPLSAY GVDSLMAVEL RNWFKKDFDA AVTVFDIMGS
NSSISAVADL VVQTSGTKQT DANV
//
