ID A0A0U1Q2D9_9BURK Unreviewed; 299 AA.
AC A0A0U1Q2D9;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:KKW68929.1};
GN ORFNames=AAV94_02855 {ECO:0000313|EMBL:KKW68929.1};
OS Lampropedia cohaerens.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Lampropedia.
OX NCBI_TaxID=1610491 {ECO:0000313|EMBL:KKW68929.1, ECO:0000313|Proteomes:UP000050580};
RN [1] {ECO:0000313|EMBL:KKW68929.1, ECO:0000313|Proteomes:UP000050580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT6 {ECO:0000313|EMBL:KKW68929.1,
RC ECO:0000313|Proteomes:UP000050580};
RA Tripathi C., Rani P., Mahato N.K., Lal R.;
RT "Draft genome sequence of Lampropedia sp. CT6, isolated from the microbial
RT mat of a hot water spring, located at Manikaran, India.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW68929.1}.
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DR EMBL; LBNQ01000012; KKW68929.1; -; Genomic_DNA.
DR RefSeq; WP_046740858.1; NZ_LBNQ01000012.1.
DR AlphaFoldDB; A0A0U1Q2D9; -.
DR STRING; 1610491.AAV94_02855; -.
DR PATRIC; fig|1610491.3.peg.600; -.
DR OrthoDB; 9777604at2; -.
DR Proteomes; UP000050580; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000050580}.
FT DOMAIN 11..166
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 170..288
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 176
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 299 AA; 31116 MW; 0E264EAA9A5B414D CRC64;
MTQEHSSKPA IAFLGTGLMG LPMATRLLDA GFPLHVWNRT AAKAAPLAQL GAHLHASAAE
AAHHAAITIS MLENGDVVRK VLEDQGVAAA MPADSLFIDM ASIQPEQARA HAQLLQARGI
RTLDAPVSGG TVGAEAGTLA IMVGGDAADF AAASAIFAAL GRATHVGGHG TGQLTKLINQ
MIVGVTIGAV AEGLLLARKG GADPAKVREA ISGGFADSRI LLLHGERMVA QDFAPRARMT
VQLKDLRNAL ATSAQLDFEP PITRLLHALF EDACREGFAD LDHSALYLAL AQRNGMKQP
//
