ID A0A0U1RNH6_MOUSE Unreviewed; 69 AA.
AC A0A0U1RNH6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Lysoplasmalogenase TMEM86B {ECO:0000256|ARBA:ARBA00039876};
DE EC=3.3.2.2 {ECO:0000256|ARBA:ARBA00035673};
DE AltName: Full=Transmembrane protein 86B {ECO:0000256|ARBA:ARBA00042674};
DE Flags: Fragment;
GN Name=Tmem86b {ECO:0000313|Ensembl:ENSMUSP00000145569.2,
GN ECO:0000313|MGI:MGI:1915505};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000145569.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000145569.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000145569.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000145569.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000145569.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline
CC or ethanolamine lysoplasmalogens, forming fatty aldehyde and
CC glycerophosphocholine or glycerophosphoethanolamine, respectively and
CC is specific for the sn-2-deacylated (lyso) form of plasmalogen.
CC {ECO:0000256|ARBA:ARBA00037660}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-
CC saturated aldehyde + sn-glycerol 3-phosphocholine;
CC Xref=Rhea:RHEA:22544, ChEBI:CHEBI:15377, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:73359, ChEBI:CHEBI:77287; EC=3.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00035598};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a
CC 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine;
CC Xref=Rhea:RHEA:16905, ChEBI:CHEBI:15377, ChEBI:CHEBI:73359,
CC ChEBI:CHEBI:77288, ChEBI:CHEBI:143890; EC=3.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00035579};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM86 family.
CC {ECO:0000256|ARBA:ARBA00007375}.
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DR AlphaFoldDB; A0A0U1RNH6; -.
DR Antibodypedia; 33044; 15 antibodies from 9 providers.
DR Ensembl; ENSMUST00000205402.2; ENSMUSP00000145569.2; ENSMUSG00000045282.8.
DR AGR; MGI:1915505; -.
DR MGI; MGI:1915505; Tmem86b.
DR VEuPathDB; HostDB:ENSMUSG00000045282; -.
DR GeneTree; ENSGT00390000007101; -.
DR OMA; HAYDRRQ; -.
DR ChiTaRS; Tmem86b; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000045282; Expressed in bone marrow and 62 other cell types or tissues.
DR ExpressionAtlas; A0A0U1RNH6; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR012506; TMEM86B-like.
DR PANTHER; PTHR31885; GH04784P; 1.
DR PANTHER; PTHR31885:SF7; LYSOPLASMALOGENASE; 1.
DR Pfam; PF07947; YhhN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 51..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 69
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000145569.2"
SQ SEQUENCE 69 AA; 7696 MW; 5E2D79B6AAF694E5 CRC64;
MVLPVMAYGL ILNSMLWRSL VWGGSASWGA VLFTFSDGVL AWDTFVYSLP FARLVTMSTY
YAAQLLLIL
//
