ID A0A0U1RQA1_MOUSE Unreviewed; 328 AA.
AC A0A0U1RQA1;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Septin 1 {ECO:0000313|Ensembl:ENSMUSP00000146307.2};
DE Flags: Fragment;
GN Name=Septin1 {ECO:0000313|Ensembl:ENSMUSP00000146307.2,
GN ECO:0000313|MGI:MGI:1858916};
GN Synonyms=Sept1 {ECO:0000313|MGI:MGI:1858916};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000146307.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000146307.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146307.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000146307.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146307.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|RuleBase:RU004560}.
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DR AlphaFoldDB; A0A0U1RQA1; -.
DR SMR; A0A0U1RQA1; -.
DR jPOST; A0A0U1RQA1; -.
DR ProteomicsDB; 348767; -.
DR Antibodypedia; 27233; 310 antibodies from 31 providers.
DR Ensembl; ENSMUST00000152267.8; ENSMUSP00000146307.2; ENSMUSG00000000486.14.
DR AGR; MGI:1858916; -.
DR MGI; MGI:1858916; Septin1.
DR VEuPathDB; HostDB:ENSMUSG00000000486; -.
DR GeneTree; ENSGT00940000161794; -.
DR ChiTaRS; Sept1; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000000486; Expressed in granulocyte and 109 other cell types or tissues.
DR ExpressionAtlas; A0A0U1RQA1; baseline and differential.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF6; SEPTIN-1; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR006698-
KW 2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR006698-2};
KW Proteomics identification {ECO:0007829|EPD:A0A0U1RQA1,
KW ECO:0007829|MaxQB:A0A0U1RQA1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 22..261
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 265..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 291..325
FT /evidence="ECO:0000256|SAM:Coils"
FT SITE 144
FT /note="Important for dimerization"
FT /evidence="ECO:0000256|PIRSR:PIRSR006698-2"
FT NON_TER 328
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000146307.2"
SQ SEQUENCE 328 AA; 37373 MW; 6703D0E80238EBB5 CRC64;
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL YEDRQVPDAS
ARTAQTLTIE RRGVEIEEGG IKVKLTLVDT PGFGDSVDCS DCWLPVVRFI EEQFEQYLRD
ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP LDVAFLRAVH EKVNIIPVIG KADALMPRET
QALKQKENIP FAVVGSCEVV RDGTRPVRGR RYSWGTVEVE NPHHCDFLNL RRMLVQTHLQ
DLKEVTHDLL YEGYRARCLQ SLARPGARDR ASRSKLSRQS ATEIPLPMLP LADTEKLIRE
KDEELRRMQE MLEKMQAQMQ QSQAQGEQ
//
