ID A0A0U1RQA2_MOUSE Unreviewed; 141 AA.
AC A0A0U1RQA2;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 {ECO:0000313|Ensembl:ENSMUSP00000146308.2};
DE Flags: Fragment;
GN Name=Hsd3b7 {ECO:0000313|Ensembl:ENSMUSP00000146308.2,
GN ECO:0000313|MGI:MGI:2141879};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000146308.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000146308.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146308.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000146308.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146308.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A0U1RQA2; -.
DR jPOST; A0A0U1RQA2; -.
DR ProteomicsDB; 361776; -.
DR Antibodypedia; 27526; 225 antibodies from 27 providers.
DR Ensembl; ENSMUST00000206674.2; ENSMUSP00000146308.2; ENSMUSG00000042289.12.
DR AGR; MGI:2141879; -.
DR MGI; MGI:2141879; Hsd3b7.
DR VEuPathDB; HostDB:ENSMUSG00000042289; -.
DR GeneTree; ENSGT00940000160236; -.
DR ChiTaRS; Hsd3b7; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000042289; Expressed in hepatobiliary system and 71 other cell types or tissues.
DR ExpressionAtlas; A0A0U1RQA2; baseline and differential.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:A0A0U1RQA2,
KW ECO:0007829|PeptideAtlas:A0A0U1RQA2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 13..53
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT NON_TER 141
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000146308.2"
SQ SEQUENCE 141 AA; 15829 MW; 74BDDF17C88329A7 CRC64;
MADSAQVPTL VYLVTGGCGF LGEHIVRMLL EREPRLRELR VFDLHLSSWL EELKAGAMKI
PHMRQSTAIP THAVKPLLSS WSSRPMEGRY TAKMGLELQG QSLSPRLLCI HLQPTVERGL
RFGGRLFRAV PASVEHGRVY V
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