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Database: UniProt
Entry: A0A0U1RRH1_HUMAN
LinkDB: A0A0U1RRH1_HUMAN
Original site: A0A0U1RRH1_HUMAN 
ID   A0A0U1RRH1_HUMAN        Unreviewed;      4859 AA.
AC   A0A0U1RRH1;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   16-JAN-2019, entry version 22.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSP00000489529};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSP00000489529};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000489529};
RN   [1] {ECO:0000313|Ensembl:ENSP00000489529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000489529}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AC010809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC055874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC067793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC087638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011520182.1; XM_011521880.2.
DR   UniGene; Hs.709373; -.
DR   PeptideAtlas; A0A0U1RRH1; -.
DR   Ensembl; ENST00000634418; ENSP00000489529; ENSG00000198838.
DR   GeneID; 6263; -.
DR   CTD; 6263; -.
DR   HGNC; HGNC:10485; RYR3.
DR   OpenTargets; ENSG00000198838; -.
DR   GeneTree; ENSGT00940000155507; -.
DR   OrthoDB; 5161at2759; -.
DR   ChiTaRS; RYR3; human.
DR   GenomeRNAi; 6263; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   ExpressionAtlas; A0A0U1RRH1; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0U1RRH1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4172   4196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4400   4420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4468   4487       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4599   4617       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4660   4681       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4740   4763       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3908   3943       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     3218   3238       {ECO:0000256|SAM:Coils}.
FT   COILED     4322   4349       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4859 AA;  550825 MW;  B32C375E0117149B CRC64;
     MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
     FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNVYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT
     TQFLSQASFI PCPVDTSQVI LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY
     AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR
     MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID
     GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN
     TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW
     SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH
     TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLASAKE
     RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ
     KQSPEIPLES LRTKALSMLT EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD
     DDVRQILLLI DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP
     ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA
     RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED
     TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDSELVR
     MMFNLLRRQY DSIGELLQAL RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM
     INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF
     CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALSLEEPDLE
     KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL
     LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVTGD DEEEEEIVHM
     GNAIMSFYSA LIDLLGRCAP EMHLIQTGKG EAIRIRSILR SLVPTEDLVG IISIPLKLPS
     LNKDGSVSEP DMAANFCPDH KAPMVLFLDR VYGIKDQTFL LHLLEVGFLP DLRASASLDT
     VSLSTTEAAL ALNRYICSAV LPLLTRCAPL FAGTEHCTSL IDSTLQTIYR LSKGRSLTKA
     QRDTIEECLL AICNHLRPSM LQQLLRRLVF DVPQLNEYCK MPLKLLTNHY EQCWKYYCLP
     SGWGSYGLAV EEELHLTEKL FWGIFDSLSH KKYDPDLFRM ALPCLSAIAG ALPPDYLDTR
     ITATLEKQIS VDADGNFDPK PINTMNFSLP EKLEYIVTKY AEHSHDKWAC DKSQSGWKYG
     ISLDENVKTH PLIRPFKTLT EKEKEIYRWP ARESLKTMLA VGWTVERTKE GEALVQQREN
     EKLRSVSQAN QGNSYSPAPL DLSNVVLSRE LQGMVEVVAE NYHNIWAKKK KLELESKGGG
     SHPLLVPYDT LTAKEKFKDR EKAQDLFKFL QVNGIIVSRG MKDMELDASS MEKRFAYKFL
     KKILKYVDSA QEFIAHLEAI VSSGKTEKSP RDQEIKFFAK VLLPLVDQYF TSHCLYFLSS
     PLKPLSSSGY ASHKEKEMVA GLFCKLAALV RHRISLFGSD STTMVSCLHI LAQTLDTRTV
     MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT QIKGVSQNIN YTTVALLPIL
     TSIFEHVTQH QFGMDLLLGD VQISCYHILC SLYSLGTGKN IYVERQRPAL GECLASLAAA
     IPVAFLEPTL NRYNPLSVFN TKTPRERSIL GMPDTVEDMC PDIPQLEGLM KEINDLAESG
     ARYTEMPHVI EVILPMLCNY LSYWWERGPE NLPPSTGPCC TKVTSEHLSL ILGNILKIIN
     NNLGIDEASW MKRIAVYAQP IISKARPDLL RSHFIPTLEK LKKKAVKTVQ EEEQLKADGK
     GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSNWL KSPDADSDQL FRMVAEVFIL
     WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS KSKMSKSGGQ DQERKKTKRR GDLYSIQTSL
     IVAALKKMLP IGLNMCTPGD QELISLAKSR YSHRDTDEEV REHLRNNLHL QEKSDDPAVK
     WQLNLYKDVL KSEEPFNPEK TVERVQRISA AVFHLEQVEQ PLRSKKAVWH KLLSKQRKRA
     VVACFRMAPL YNLPRHKINN FFLSTFQQVW LEKVNEKTQY DRLIPILMKS PKVEEEEEEE
     TEKQPDPLHQ IILYFSRNAL TERSKLEDDP LYTSYSSMMA KSCQSGEDEE EDEDKEKTFE
     EKEMEKQKTL YQQARLHERG AAEMVLQMIS ASKGEMSPMV VETLKLGIAI LNGGNAGVQQ
     KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT REKVLQNDEF
     TRDLFRFLQL LCEGHNSDFQ NFLRTQMGNT TTVNVIISTV DYLLRLQESI SDFYWYYSGK
     DIIDESGQHN FSKALAVTKQ IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ
     MKLSQDSSQI ELLKELLDLL QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE SSTNVEMILK
     FFDMFLKLKD LTSSDTFKEY DPDGKGIISK KEFQKAMEGQ KQYTQSEIDF LLSCAEADEN
     DMFNYVDFVD RFHEPAKDIG FNVAVLLTNL SEHMPNDSRL KCLLDPAESV LNYFEPYLGR
     IEIMGGAKKI ERVYFEISES SRTQWEKPQV KESKRQFIFD VVNEGGEQEK MELFVNFCED
     TIFEMQLASQ ISESDSADRP EEEEEDEDSS YVLEIAGEEE EDGSLEPASA FAMACASVKR
     NVTDFLKRAT LKNLRKQYRN VKKMTAKELV KVLFSFFWML FVGLFQLLFT ILGGIFQILW
     STVFGGGLVE GAKNIRVTKI LGDMPDPTQF GIHDDTMEAE RAEVMEPGIT TELVHFIKGE
     KGDTDIMSDL FGLHPKKEGS LKHGPEVGLG DLSEIIGKDE PPTLESTVQK KRKAQAAEMK
     AANEAEGKVE SEKADMEDGE KEDKDKEEEQ AEYLWTEVTK KKKRRCGQKV EKPEAFTANF
     FKGLEIYQTK LLHYLARNFY NLRFLALFVA FAINFILLFY KVTEEPLEEE TEDVANLWNS
     FNDEEEEEAM VFFVLQESTG YMAPTLRALA IIHTIISLVC VVGYYCLKVP LVVFKREKEI
     ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN TPSFPNNYWD KFVKRKVINK YGDLYGAERI
     AELLGLDKNA LDFSPVEETK AEAASLVSWL SSIDMKYHIW KLGVVFTDNS FLYLAWYTTM
     SVLGHYNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF
     FRKFYNKSED DDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDP YEMYRIVFDI
     TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVREDMETKC FICGIGNDYF DTTPHGFETH
     TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
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