ID A0A0U2CJS8_ICTTR Unreviewed; 174 AA.
AC A0A0U2CJS8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|ARBA:ARBA00021095, ECO:0000256|RuleBase:RU004430};
DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU004430};
GN Name=ND6 {ECO:0000313|EMBL:AKJ86825.1};
GN Synonyms=MT-ND6 {ECO:0000313|Ensembl:ENSSTOP00000027634.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OG Mitochondrion {ECO:0000313|EMBL:AKJ86825.1,
OG ECO:0000313|Ensembl:ENSSTOP00000027634.1}.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|EMBL:AKJ86825.1};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AKJ86825.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24409865; DOI=10.3109/19401736.2013.861440;
RA Zhang K.J., Liu L., Rong X., Zhang G.H., Liu H., Liu Y.H.;
RT "The complete mitochondrial genome of Paradoxornis webbianus
RT (Passeriformes, Muscicapidae).";
RL Mitochondrial DNA 26:879-880(2015).
RN [3] {ECO:0000313|Ensembl:ENSSTOP00000027634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000256|RuleBase:RU004430}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000766,
CC ECO:0000256|RuleBase:RU004430};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC membrane {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU004430}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family.
CC {ECO:0000256|ARBA:ARBA00005698, ECO:0000256|RuleBase:RU004430}.
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DR EMBL; KP698974; AKJ86825.1; -; Genomic_DNA.
DR RefSeq; YP_009145197.1; NC_027278.1.
DR STRING; 43179.ENSSTOP00000027634; -.
DR Ensembl; ENSSTOT00000032715.1; ENSSTOP00000027634.1; ENSSTOG00000030367.1.
DR GeneID; 24576601; -.
DR CTD; 4541; -.
DR GeneTree; ENSGT00390000003988; -.
DR OrthoDB; 4268134at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl.
DR Gene3D; 1.20.120.1200; NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR PANTHER; PTHR11435; NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6; 1.
DR PANTHER; PTHR11435:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU004430};
KW Membrane {ECO:0000256|RuleBase:RU004430};
KW Mitochondrion {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:AKJ86825.1};
KW NAD {ECO:0000256|RuleBase:RU004430};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Respiratory chain {ECO:0000256|RuleBase:RU004430};
KW Signal {ECO:0000256|SAM:SignalP};
KW Translocase {ECO:0000256|RuleBase:RU004430};
KW Transmembrane {ECO:0000256|RuleBase:RU004430};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004430};
KW Transport {ECO:0000256|RuleBase:RU004430};
KW Ubiquinone {ECO:0000256|RuleBase:RU004430}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..174
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015048896"
FT TRANSMEM 30..46
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 53..74
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 86..109
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 144..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
SQ SEQUENCE 174 AA; 19063 MW; CA4620FEB588471B CRC64;
MTYMTYLLSM LFVLGFVGFS SKPSPIYGGL GLIVSGGIGC GVVLYFGGSF LGLMVFLIYL
GGMLVVFGYT TAMATEEYPE TWGSSVVIWG ALLLGFLVEF LIVMFMVLYD EVEVVIEFKD
SGNWMVFEGD ELGLIREDSM GVAAMYNCGS WLMVVAGWSL FVSIFIVIEI TRGN
//
