ID A0A0U2IMN2_9BACL Unreviewed; 353 AA.
AC A0A0U2IMN2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:ALS23019.1};
GN ORFNames=IJ22_26460 {ECO:0000313|EMBL:ALS23019.1};
OS Paenibacillus naphthalenovorans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=162209 {ECO:0000313|EMBL:ALS23019.1, ECO:0000313|Proteomes:UP000061660};
RN [1] {ECO:0000313|Proteomes:UP000061660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=32O-Y {ECO:0000313|Proteomes:UP000061660};
RA Butler R.III., Wang J., Stark B.C., Pombert J.-F.;
RT "Complete genome sequences of two moderately thermophilic Paenibacillus
RT species.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ALS23019.1, ECO:0000313|Proteomes:UP000061660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=32O-Y {ECO:0000313|EMBL:ALS23019.1,
RC ECO:0000313|Proteomes:UP000061660};
RX PubMed=26868401;
RA Butler R.R.III., Wang J., Stark B.C., Pombert J.F.;
RT "Complete Genome Sequences of Two Interactive Moderate Thermophiles,
RT Paenibacillus napthalenovorans 32O-Y and Paenibacillus sp. 32O-W.";
RL Genome Announc. 4:e01717-15(2016).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP013652; ALS23019.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0U2IMN2; -.
DR STRING; 162209.IJ22_26460; -.
DR KEGG; pnp:IJ22_26460; -.
DR PATRIC; fig|162209.4.peg.2817; -.
DR Proteomes; UP000061660; Chromosome.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:ALS23019.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000061660}.
FT DOMAIN 45..341
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 353 AA; 38910 MW; 605D1A506D0B2247 CRC64;
MPLPLIHKLQ AMSFQIQEEV ERMVDVVQDK KITLSREKAG WIFQKMLEIR KFEDKVHELF
AQGKLPGFVH LYAGEEAVAV GVCAHLDDKD SITSTHRGHG HCIAKGCDLD GMMAELFGKA
TGLCKGKGGS MHIADFNKGM LGANGIVGGG YPLACGSALT AKYKKTNAVS VCFFGDGANN
QGTFHEGINL ASIWKLPVVF IAENNGYGEA TPFHMASSCK TIAERAIAYN IPGIRVDGKD
VLAVYQAAEE AIQRARRGEG PTLIECVTYR NYGHFEGDAQ KYKKEEEKKE HLNEKDAIQQ
FRAYLLNQQL FTEADLAEIE TSIDQAVEAA IEYSEQSPFP DESELLTDVY VSY
//
