ID A0A0U2QMT5_9ALTE Unreviewed; 1157 AA.
AC A0A0U2QMT5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=AT746_11375 {ECO:0000313|EMBL:ALS98811.1};
OS Lacimicrobium alkaliphilum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Lacimicrobium.
OX NCBI_TaxID=1526571 {ECO:0000313|EMBL:ALS98811.1, ECO:0000313|Proteomes:UP000068447};
RN [1] {ECO:0000313|EMBL:ALS98811.1, ECO:0000313|Proteomes:UP000068447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YelD216 {ECO:0000313|EMBL:ALS98811.1,
RC ECO:0000313|Proteomes:UP000068447};
RA Kim S.-G., Lee Y.-J.;
RT "Complete genome of Lacimicrobium alkaliphilum KCTC 32984.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; CP013650; ALS98811.1; -; Genomic_DNA.
DR RefSeq; WP_062480396.1; NZ_CP013650.1.
DR AlphaFoldDB; A0A0U2QMT5; -.
DR STRING; 1526571.AT746_11375; -.
DR KEGG; lal:AT746_11375; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000068447; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000068447}.
FT DOMAIN 623..784
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 805..959
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1157 AA; 130237 MW; B289D0DB92D7BBEE CRC64;
MSSIFSPDLP AKAGDHQQWG NLQGSSLALA IANASERVKG SVLLITADTP SALKLARELQ
SFVSEIEVKI FPDWETLPYD NFSPHQDIIS QRLETLFHLT QPQPCIYVVP VNTLLQRLAP
VDYLAKYLLL LEQGQHLDLD SFRQGLERAG YTAVSQVMSH SEFCVRGSII DLFPMGSKTP
YRIDLFDDEI DSIRIFDPDS QRSEDKVEQI RMLPAHEFPT DKEAIDRFRL QFLDRFDASN
ARESVYHQVS KGLMPAGIEY YLPLFFEHTA TLFDYLHQDS LVLMHGDLIN AAEFYWADVQ
ERYEQHKYNP LKPLLSPAEI FLRVEELFNL IKQRARISVG HQSLEPKAGR TNFATTALPD
IAVKPQLKSP MASLQQQLKV WQQQGVRVLF SVESQGRRES LLEMLKKIQI SPKEVSDLGT
FLCGHQQLGI VISDLEHSFM LDESDGRLVL ITETELLGHK ISQRRLRKKQ QATDEAAVIR
NLAELNIGQP VVHLDHGVGR YLGLQTLDAG GIATEYLTIE YANQAKLYVP VSSLHLISRY
SGGDLDSAPL HHLGTETWAK ARKKAAEKVR DVAAQLLDVY ARRAAKPGFA IKINWDEYES
FANSFPFEET ADQQQAINAV IQDMGSPIAM DRLVCGDVGF GKTEVAMRAA FLAANGGKQV
AILVPTTLLA QQHYENFKDR FADWPFRIEV MSRFGSGKEH KEIIQGLNDG KVDIVVGTHK
LLQDDVKFAE LGLVIIDEEH RFGVRQKEKF KALRADVDIL TLTATPIPRT LNMALSGMRD
LSIIATAPAK RLAIKTFVRQ RDKQLIREAI MREILRGGQV YFLHNEVETI DKTAAEIEEI
VPEARVGIGH GQMRERDLER VMSDFYHQRF NVLVCSTIIE TGIDIPSANT IIMDRADHLG
LAQLHQLRGR VGRSHHQAYA YLLTPHPKRM TKDAHKRLEA IASLEDLGAG FALATHDLEI
RGAGELLGDD QSGQIATVGF SLYMEMLDKA VEALKEGKEP SLDESLSSHT DIELRIPALL
PEDYIHDVNI RLSLYKKIAN CKNKDELDDV RVELIDRFGL LPDAAKNLMT IAELKLEAKK
VGISKIEASS QGGFVEFDQD TPVDPGFIIQ LLQSQPAVYK LDGPQKLRFN IKTEQHQQRV
TLVQDMLTQF KRKLQAA
//