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Database: UniProt
Entry: A0A0U2TTQ4_9EURY
LinkDB: A0A0U2TTQ4_9EURY
Original site: A0A0U2TTQ4_9EURY 
ID   A0A0U2TTQ4_9EURY        Unreviewed;       495 AA.
AC   A0A0U2TTQ4;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   16-JAN-2019, entry version 16.
DE   RecName: Full=Archaeal glutamate synthase [NADPH] {ECO:0000256|PIRNR:PIRNR006429};
DE            EC=1.4.1.13 {ECO:0000256|PIRNR:PIRNR006429};
GN   Name=gltA {ECO:0000313|EMBL:ALT69235.1};
GN   ORFNames=sm9_1454 {ECO:0000313|EMBL:ALT69235.1};
OS   Methanobrevibacter millerae.
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=230361 {ECO:0000313|EMBL:ALT69235.1, ECO:0000313|Proteomes:UP000067738};
RN   [1] {ECO:0000313|EMBL:ALT69235.1, ECO:0000313|Proteomes:UP000067738}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM9 {ECO:0000313|EMBL:ALT69235.1,
RC   ECO:0000313|Proteomes:UP000067738};
RA   Leahy S.C., Kelly W.J., Pacheco D.M., Li D., Altermann E.,
RA   Attwood G.T.;
RT   "The complete genome sequence of the rumen methanogen
RT   Methanobrevibacter millerae SM9.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-
CC         glutamine + NADPH; Xref=Rhea:RHEA:15501, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:58359; EC=1.4.1.13;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006429};
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006429};
CC   -!- SIMILARITY: Belongs to the glutamate synthase family.
CC       {ECO:0000256|PIRNR:PIRNR006429}.
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DR   EMBL; CP011266; ALT69235.1; -; Genomic_DNA.
DR   RefSeq; WP_058739481.1; NZ_CP011266.1.
DR   EnsemblBacteria; ALT69235; ALT69235; sm9_1454.
DR   GeneID; 26736401; -.
DR   KEGG; mmil:sm9_1454; -.
DR   PATRIC; fig|230361.4.peg.1500; -.
DR   OrthoDB; 14505at2157; -.
DR   Proteomes; UP000067738; Chromosome.
DR   GO; GO:0004355; F:glutamate synthase (NADPH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd02808; GltS_FMN; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR024188; GltB.
DR   InterPro; IPR002932; Glu_synthdom.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF01645; Glu_synthase; 1.
DR   PIRSF; PIRSF006429; GOGAT_lg_2; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 3.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR006429};
KW   Complete proteome {ECO:0000313|Proteomes:UP000067738};
KW   Flavoprotein {ECO:0000256|PIRNR:PIRNR006429};
KW   FMN {ECO:0000256|PIRNR:PIRNR006429};
KW   Glutamate biosynthesis {ECO:0000256|PIRNR:PIRNR006429};
KW   NADP {ECO:0000256|PIRNR:PIRNR006429};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR006429};
KW   Reference proteome {ECO:0000313|Proteomes:UP000067738}.
FT   DOMAIN       23     54       4Fe-4S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51379}.
FT   DOMAIN       55     84       4Fe-4S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51379}.
FT   DOMAIN      401    430       4Fe-4S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51379}.
SQ   SEQUENCE   495 AA;  53197 MW;  6C152BF7B82AC260 CRC64;
     MSFTVERKIE ICKQSNDRPG CCWYLCDNPN KTACKNCYSC YSNCPHNVYE VINDEPLPIH
     QENCVGCKIC EEMCPTHAIY VRPLVDEGRG VWSNSTMVEI KRKSQSGSYK VRGCGLTRKI
     PTFDDLSILP AQVSRPPIDS YRETCKTSVV LGDRFAENPI EIDTPIMIGA MSFGALSKEA
     KIALAIGSSK VGSIANTGEG GMLPEERQHA DKLIAQYASG RFGVSAEYLN SAEAVEIKIG
     QGAKSGMGGH LLSHKVTAEV ARVRNIPEGT SALSPARHMD IVGPEDLGMK INQLREITDW
     KIPIIVKFAS GRVEQDVKIA AKAGADIIVV DGMQGGTGAG PEVVTEHAGI PTIEAIVKAD
     DALKEINLRS EVSLVAAGGI RSGADVAKAI ALGADAVYIA TSALISIGCK VCQSCSEGIC
     PKGIATQDRV LRRRLDPIRK GQQVANYIEA MTQEVTALTQ QAGNTDIENL ERQDLVALTM
     EASQLTGVPM VSKKY
//
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