ID A0A0U2UAM1_9BURK Unreviewed; 508 AA.
AC A0A0U2UAM1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ALV08913.1};
GN ORFNames=DES44_4839 {ECO:0000313|EMBL:REG09425.1}, RD2015_4472
GN {ECO:0000313|EMBL:ALV08913.1};
OS Roseateles depolymerans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Roseateles.
OX NCBI_TaxID=76731 {ECO:0000313|EMBL:ALV08913.1, ECO:0000313|Proteomes:UP000060699};
RN [1] {ECO:0000313|EMBL:ALV08913.1, ECO:0000313|Proteomes:UP000060699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 42856 {ECO:0000313|EMBL:ALV08913.1,
RC ECO:0000313|Proteomes:UP000060699};
RA Kim K.M.;
RT "Complete genome of Roseateles depolymerans KCTC 42856.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:REG09425.1, ECO:0000313|Proteomes:UP000256283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11813 {ECO:0000313|EMBL:REG09425.1,
RC ECO:0000313|Proteomes:UP000256283};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CP013729; ALV08913.1; -; Genomic_DNA.
DR EMBL; QUMT01000008; REG09425.1; -; Genomic_DNA.
DR RefSeq; WP_058936783.1; NZ_QUMT01000008.1.
DR AlphaFoldDB; A0A0U2UAM1; -.
DR STRING; 76731.RD2015_4472; -.
DR KEGG; rdp:RD2015_4472; -.
DR PATRIC; fig|76731.3.peg.4581; -.
DR OrthoDB; 5287258at2; -.
DR Proteomes; UP000060699; Chromosome.
DR Proteomes; UP000256283; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR041040; 3HCDH_RFF.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF18321; 3HCDH_RFF; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000060699}.
FT DOMAIN 20..197
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 200..295
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 355..424
FT /note="3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-
FT fold"
FT /evidence="ECO:0000259|Pfam:PF18321"
FT DOMAIN 425..503
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 508 AA; 53819 MW; 1072CDB2AFE42B55 CRC64;
MTAAHKPWRI TTAAPADAPV AVIGAGVMGA GIAQVAAQAG HPVQLMDLRE GAAQAAIDKI
GQALAALVSK GRMADEERTA VMARLRPAAS VDDLADAALV VEVIIEQLAP KQALLKALDT
LLPADALIAS NTSSISITAL ANGMTTPQRL VGMHFFNPVP LMKLVEVVWG AETDPDAAQA
IDALARRWNK TPVHAKSTPG FIVNRIARPY YAESLQVLQE QGATPAVVDR ALRGAGFRMG
PCELMDLIGH DTNALVTQSV FEANFGDKRF QPSLVQRALV DGGRLGRKVG KGFYEGVPQA
APPVPVPTTP APAVTLCGQG PLVEHLAGWL AHRGLTVATA PEAGWQGLAL EGLELHLTDG
RCAAELAHHR QQPALAVMDW PVAPDRADGL AVAFGPKVTE AQQAMAAELL RHLGWELLTL
RDIPGLVVAR TIAMLVNEAA DAVWQGVCDA PAADTAMKLG VNYPAGPFEW LEQLGAPTVV
QLLEGLFTSY RSERYRVSPL LKHRLWAA
//
