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Database: UniProt
Entry: A0A0U2VUL0_9BACL
LinkDB: A0A0U2VUL0_9BACL
Original site: A0A0U2VUL0_9BACL 
ID   A0A0U2VUL0_9BACL        Unreviewed;       294 AA.
AC   A0A0U2VUL0;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   31-JUL-2019, entry version 15.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=IJ22_28500 {ECO:0000313|EMBL:ALS23223.1}, PN4B1_26300
GN   {ECO:0000313|EMBL:GCL72703.1};
OS   Paenibacillus naphthalenovorans.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC   Paenibacillus.
OX   NCBI_TaxID=162209 {ECO:0000313|EMBL:ALS23223.1, ECO:0000313|Proteomes:UP000061660};
RN   [1] {ECO:0000313|Proteomes:UP000061660}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=32O-Y {ECO:0000313|Proteomes:UP000061660};
RA   Butler R.III., Wang J., Stark B.C., Pombert J.-F.;
RT   "Complete genome sequences of two moderately thermophilic
RT   Paenibacillus species.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ALS23223.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=32O-Y {ECO:0000313|EMBL:ALS23223.1};
RA   Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ALS23223.1, ECO:0000313|Proteomes:UP000061660}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=32O-Y {ECO:0000313|EMBL:ALS23223.1,
RC   ECO:0000313|Proteomes:UP000061660};
RX   PubMed=26868401;
RA   Butler R.R.III., Wang J., Stark B.C., Pombert J.F.;
RT   "Complete Genome Sequences of Two Interactive Moderate Thermophiles,
RT   Paenibacillus napthalenovorans 32O-Y and Paenibacillus sp. 32O-W.";
RL   Genome Announc. 4:e01717-15(2016).
RN   [4] {ECO:0000313|EMBL:GCL72703.1, ECO:0000313|Proteomes:UP000299945}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4B1 {ECO:0000313|EMBL:GCL72703.1,
RC   ECO:0000313|Proteomes:UP000299945};
RA   Ha-Thanh L.T., Ngoc-Thi T.V., Shintani M., Moriuchi R., Dohra H.,
RA   Hoang-Loc N., Kimbara K.;
RT   "Isolation and characterization of a moderate thermophilic
RT   Paenibacillus naphthalenovorans strain 4B1 capable of degrading
RT   dibenzofuran from dioxin-contaminated soil in Vietnam.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; CP013652; ALS23223.1; -; Genomic_DNA.
DR   EMBL; BJCS01000007; GCL72703.1; -; Genomic_DNA.
DR   RefSeq; WP_062409243.1; NZ_CP013652.1.
DR   EnsemblBacteria; ALS23223; ALS23223; IJ22_28500.
DR   KEGG; pnp:IJ22_28500; -.
DR   PATRIC; fig|162209.4.peg.3038; -.
DR   KO; K04518; -.
DR   OrthoDB; 1280729at2; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000061660; Chromosome.
DR   Proteomes; UP000299945; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000061660,
KW   ECO:0000313|Proteomes:UP000299945};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000061660}.
FT   DOMAIN        3    191       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      206    283       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        184    184       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   294 AA;  32766 MW;  75F80127DCE8EEDB CRC64;
     MKRVSLLGPG TFTEESAHYF LGKDGFEYVN CKLIADVFRA TVDGTTDFSV IPIENTFEGS
     VSLHVDWLVH DVDLPIQAEW VYPISINLLS IPAVENEPDA FEKSCGRIRK IYSHGVTLAQ
     CQKFLREHLP HVELEQVGSN GEAARLVREL NDPAIAALAP QAAGELYRLQ TLAAGVQDHQ
     NNYTRFVLIG REKPVMKTSA GCKTTILVTL PEDYPGALHQ VLSAFAWRRI NLSKIESRPT
     KKKLGNYFFY IDIEASMDSV LLPAALQEIE AIGCQVRILG CYPTYSYESE TSEV
//
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