ID A0A0U2Y343_9BURK Unreviewed; 773 AA.
AC A0A0U2Y343;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=AT302_15985 {ECO:0000313|EMBL:ALS61044.1};
OS Pandoraea norimbergensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Pandoraea.
OX NCBI_TaxID=93219 {ECO:0000313|EMBL:ALS61044.1, ECO:0000313|Proteomes:UP000060277};
RN [1] {ECO:0000313|Proteomes:UP000060277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11628 {ECO:0000313|Proteomes:UP000060277};
RA Ee R., Lim Y.-L., Yong D., Yin W.-F., Chan K.-G.;
RT "Complete genome sequence of Pandoraea norimbergensis DSM 11628.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP013480; ALS61044.1; -; Genomic_DNA.
DR RefSeq; WP_058377957.1; NZ_CP013480.3.
DR AlphaFoldDB; A0A0U2Y343; -.
DR STRING; 93219.AT302_15985; -.
DR KEGG; pnr:AT302_15985; -.
DR OrthoDB; 5905204at2; -.
DR Proteomes; UP000060277; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 6..283
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 284..587
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 773 AA; 86022 MW; E687D6EDD34988D2 CRC64;
MPDLLANLNP EQLAAVTLPD EPALILAGAG SGKTRVLTTR IAWLIQQGHV GPAGILAVTF
TNKAAKEMQA RLGAMLPISP RAMWIGTFHG LCNRMLRAHF RDAGLPQSFQ ILDQADQLSA
IKRMMKAANV DDEKFPPKNL QYFINNAKEQ GLRPHEVEAN DAFNQKFVEL YASYQEQCQR
EGVVDFAELL LRCFELLKHN EPLRVHYQTR FRHILVDEFQ DTNKLQYAWL KMLAGGNSAV
FAVGDDDQSI YAFRGANVGN MADFEREFRV RYMIKLEQNY RSHGNILDAA NALISNNARR
LGKNLRTDAG HGEPIRVYEA ATDLQEASWL VEEIKALVAQ GLSRQDVAIL YRSNAQSRVM
EHALVGAGIA YRVYGGLRFF ERQEVKHALA YLRLIENPND DTAFVRVVNF PTRGIGARSL
EQLADAARLY NCSMYAAVPY MTGKAGTNLT AFVRLIEQMR RETERLTLPE VVTHVVDASG
LITHYQSEKE GQDRIENLQE LVHAATAFIA EEGYGLDAPA RLIAMRPALP GAPDVLASPD
GVVDADTPVE MTPLAGFLSH ASLEAGDNQA EAGQDAVQLM TVHAAKGLEF TAVFVTGLEE
GLFPHENSAQ ELDGLEEERR LMYVAITRAK ERLYLSFTQS RMLHGQTRYN VRSRFFEEIP
EEVLKFLTPR AQPGARAAQT EPAWGRDWFS RPQVSAPRQE EWAATKSEQA LADRSRSAGT
GFKVGQGVFH TKFGEGKIIG LEGAGDEARA HVKFGRHGEK WLALAVAKLQ PIE
//
