ID   A0A0U3CTM0_9EURY        Unreviewed;      1117 AA.
AC   A0A0U3CTM0;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Adhesin-like protein with cysteine protease domain {ECO:0000313|EMBL:ALT69023.1};
GN   ORFNames=sm9_1242 {ECO:0000313|EMBL:ALT69023.1};
OS   Methanobrevibacter millerae.
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=230361 {ECO:0000313|EMBL:ALT69023.1, ECO:0000313|Proteomes:UP000067738};
RN   [1] {ECO:0000313|EMBL:ALT69023.1, ECO:0000313|Proteomes:UP000067738}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM9 {ECO:0000313|EMBL:ALT69023.1,
RC   ECO:0000313|Proteomes:UP000067738};
RA   Leahy S.C., Kelly W.J., Pacheco D.M., Li D., Altermann E., Attwood G.T.;
RT   "The complete genome sequence of the rumen methanogen Methanobrevibacter
RT   millerae SM9.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   EMBL; CP011266; ALT69023.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0U3CTM0; -.
DR   KEGG; mmil:sm9_1242; -.
DR   PATRIC; fig|230361.4.peg.1284; -.
DR   Proteomes; UP000067738; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02619; Peptidase_C1; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR   InterPro; IPR039448; Beta_helix.
DR   InterPro; IPR040528; Lectin-like.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR012334; Pectin_lyas_fold.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR003368; POMP_repeat.
DR   NCBIfam; TIGR01376; POMP_repeat; 1.
DR   PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF13229; Beta_helix; 1.
DR   Pfam; PF02415; Chlam_PMP; 1.
DR   Pfam; PF18560; Lectin_like; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF51126; Pectin lyase-like; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:ALT69023.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Protease {ECO:0000313|EMBL:ALT69023.1};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          483..711
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   1117 AA;  124556 MW;  7011A663F218BE4A CRC64;
     MVDIMNKYII GLVLVLFMFS IGSVCAGDME NTYELADGGS NSPATFTDLK NNITASENEF
     SMSSDYKFNK EADSDFLNPK NKNNITIDQK NFVINGNNHT IDADSTEGLS LFNLKGSNIT
     INDLTIKNVL NMSINSKSNL TLNNVKFINS GTINDPVIYS ASNLTLNECI MENISGYGIR
     IQSAKSLTVK DSVFSNSKTK MGFINARTET VRLDNCVFEN IESEYGAALY YNGIELFVEN
     CRFNNLHSSL TGGAIAVKGI PLNNMTKKYP HETRIVIEKS IFSNVSSEKN GGAIFTDMGG
     MYFENNSTAG DMLISDSNFI NCKSEFGGAI LNLNGALYIL NSSFTNNEAS VSGGALYTSY
     SDLIIEDSLF KDNNALKYGG AIYSELNATI IDNCSFISNK VDNSSEFNPN TIYNYDTSTY
     IRNSFFNNSK QSISSLFTKE FIEENNIWND DEFYTNLSIY PIAYTDEGLE LTLINNSINV
     TDLPSKFDLR DWGWVTPIKD QGRMGACWVF GTIAALESAL LKATGTVYDL SENNVQNSEL
     IYSRYGSTSN FEGGFSLDAL GYILSWMGVL PQEDDIYDQA GKISDILDSI NKIHIQDALL
     IPIKRDENKL CYNQTGELIK RAIIEYGAVT FTYAGDGKYY NEKTTSIYNN NTYEPNHEVA
     VIGWDDNYPK EKFNITPPGN GAWIIKNSWG KEWGDGGYAY ISYYDTSVYG KDKDTIDYTV
     AFIIENTENY TYNYQTDFSG LKNFTSNYTF YSNEFEAVEK ADLAAVGTYF NDTGVYYEFK
     IYVNGELKLT QNGTSPFAGF RTIKLNKNIP VKENDTFKVV FKSNNVPFQD KSRQHLLPEM
     SYVSSDANTW IDFSKKNMTV CLKVYTLESK NQIITEDLVK IYKNDSRFEA EIGAVNESVA
     FEINGMNYTR ISDENGTAKI AINLNPGNYT IKTTYNEATV ENTITVLPTL MAENLIKYYK
     NESQFYISLI DGAGKAVPNA NITMNINGVF YNRTTNANGT ARLNINLNPG EYILTAIDPL
     IGLQMSYSIT VLPVLSAEDI NMTYMDGTQF AATLLDETGK ALAGVNITFN INGVFYNRTT
     DENGTARLNI RLMAGEYIIT SMYENGAATS NKVTIRS
//