ID A0A0U3D5M5_9BURK Unreviewed; 524 AA.
AC A0A0U3D5M5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ALV08918.1};
GN ORFNames=DES44_4834 {ECO:0000313|EMBL:REG09420.1}, RD2015_4477
GN {ECO:0000313|EMBL:ALV08918.1};
OS Roseateles depolymerans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Roseateles.
OX NCBI_TaxID=76731 {ECO:0000313|EMBL:ALV08918.1, ECO:0000313|Proteomes:UP000060699};
RN [1] {ECO:0000313|EMBL:ALV08918.1, ECO:0000313|Proteomes:UP000060699}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 42856 {ECO:0000313|EMBL:ALV08918.1,
RC ECO:0000313|Proteomes:UP000060699};
RA Kim K.M.;
RT "Complete genome of Roseateles depolymerans KCTC 42856.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:REG09420.1, ECO:0000313|Proteomes:UP000256283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11813 {ECO:0000313|EMBL:REG09420.1,
RC ECO:0000313|Proteomes:UP000256283};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP013729; ALV08918.1; -; Genomic_DNA.
DR EMBL; QUMT01000008; REG09420.1; -; Genomic_DNA.
DR RefSeq; WP_058936786.1; NZ_QUMT01000008.1.
DR AlphaFoldDB; A0A0U3D5M5; -.
DR STRING; 76731.RD2015_4477; -.
DR KEGG; rdp:RD2015_4477; -.
DR PATRIC; fig|76731.3.peg.4586; -.
DR OrthoDB; 8868802at2; -.
DR Proteomes; UP000060699; Chromosome.
DR Proteomes; UP000256283; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000060699}.
FT ACT_SITE 80
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 12..15
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 80
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 197
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 348
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 357
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 361
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 524 AA; 57729 MW; 7D378190EC7C7BBD CRC64;
MKAIEDILIV GGGTAGWLTA AFLAQQLGTA HGGVRITLVE SSDIGIIGVG EGTFPSIRGT
LSAIGISESR FLQACSATFK QGVQFNDWVR PPVNDRGPGE SGRDHYFHPF SLPSQRPGAP
ELLPYWLMGE AGPDRAFAEA VTLQKAVVDA RHGPKRPTDG DYLGALNYAY HFDAGRFAGL
LAEQAQSLGV KRVIATVDQV ELDEQGAIAA VVTREAGVLR AGLYVDCSGF HARLIGQALG
SSFTSLNDVL FVDRALAMQV PYARPDAPIA SCTLSTAQRN GWIWDIGLQE RRGIGHVYSS
RHTDDEQAER ELRRYIGPAS DALSPRKLTL NVGYRETQWV KNCVAVGLSG GFLEPLESSG
IGLIETAAYL IAQLFPFDGD TAPVARHFNR FMAERYARIV DFIKLHYALT KRRDTAFWRD
NADPATHPDS LKDKLAMWRQ RPPQRLDFIT DVEMYLPASW QYVLYGMEYE TQLDAARAPL
QRAEDARKEF GMIAQLGQHA VRDLPRHRDL IETMLSRAGL KMAA
//