ID A0A0U3F419_9BURK Unreviewed; 784 AA.
AC A0A0U3F419;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=AT984_03885 {ECO:0000313|EMBL:ALT79616.1};
OS Paucibacter sp. KCTC 42545.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Roseateles.
OX NCBI_TaxID=1768242 {ECO:0000313|EMBL:ALT79616.1, ECO:0000313|Proteomes:UP000056576};
RN [1] {ECO:0000313|EMBL:ALT79616.1, ECO:0000313|Proteomes:UP000056576}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 42545 {ECO:0000313|EMBL:ALT79616.1,
RC ECO:0000313|Proteomes:UP000056576};
RA Kim S.-G., Lee Y.-J.;
RT "Complete genome of Paucibacter sp. KCTC 42545.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP013692; ALT79616.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0U3F419; -.
DR STRING; 1768242.AT984_03885; -.
DR KEGG; pkt:AT984_03885; -.
DR Proteomes; UP000056576; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000056576}.
FT DOMAIN 3..282
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 283..590
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 784 AA; 86877 MW; DAD5892851C2E444 CRC64;
MLKNLNPEQL AAVTAPAEPV LILAGAGSGK TRVLTTRIAW LLQTGQASPG GIMAVTFTNK
ASKEMQTRLS TMLPVNVRGM WIGTFHGLCN RFLRAHWKLA GLPQGFQILD SSDTVSAIKR
VIKAMKLDEE RYVAKQVSWF IASAKEDAQR PRDIQPHDEQ SRTMVAIYQA YEDQCAREGV
VDFAELMLRS YELMRDNAAV RDHYQRRFQH LLVDEFQDTN KLQYAWLKMF APPSKQQAVF
AVGDDDQSIY AFRGARVGNM VDFEREYRVA KVIKLEHNYR SFGNILDSAN ELISRNTKRL
GKNLRTEAGP GEPVRVYEAP SDFAEAHWLI EEAQALHRQG LSRKEIAILY RSNAQSRVIE
SALFNASIPY RVYGGLRFFE RAEVKHALSY LRLLENPNDD TSFLRVVNFP TRGIGARTIE
LLQDAARASG RSLYQSVGAV AGKGGSNLMG FTSLIDSTRN LTQGLTLREI IEQILETSGL
AEFYRNDKDG AERLENLGEL VNAAEAFVTQ EGFGKDAVAL PVDELSPGAI SDGFPQAVAP
ANFAMPDAET GEIMSPLAAF LTHASLEAGD NQAQAGQDAV QLMTVHSAKG LEFDAVFITG
LEEGLFPHEN SLTDHDGVEE ERRLMYVAIT RARQRLYLCF SQTRMLHGQT RYNVKSRFFD
ELPEASLKWL TPRNQGFGSG YAKEYQDAWS RGSGLKSVVG AGRSEKAEYA QPPVPRSMKA
AAAEKVAAEF GGLKVGKGVF HTKFGEGVLM TLEGSGQDAR AQVNFGRHGM KWLALSVAKL
TPID
//
