ID A0A0U3G2Q3_9CREN Unreviewed; 345 AA.
AC A0A0U3G2Q3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Methylene-tetrahydrofolate reductase C-terminal domain-containing protein {ECO:0000259|Pfam:PF12225};
GN ORFNames=EYM_05490 {ECO:0000313|EMBL:ALU12588.1};
OS Ignicoccus islandicus DSM 13165.
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Ignicoccus.
OX NCBI_TaxID=940295 {ECO:0000313|EMBL:ALU12588.1, ECO:0000313|Proteomes:UP000060778};
RN [1] {ECO:0000313|EMBL:ALU12588.1, ECO:0000313|Proteomes:UP000060778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13165 {ECO:0000313|EMBL:ALU12588.1,
RC ECO:0000313|Proteomes:UP000060778};
RA Podar M.;
RT "Comparative genomics of Ignicoccus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
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DR EMBL; CP006867; ALU12588.1; -; Genomic_DNA.
DR RefSeq; WP_075050012.1; NZ_CP006867.1.
DR AlphaFoldDB; A0A0U3G2Q3; -.
DR STRING; 940295.EYM_05490; -.
DR GeneID; 30680481; -.
DR KEGG; iis:EYM_05490; -.
DR OrthoDB; 28177at2157; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000060778; Chromosome.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR InterPro; IPR022026; MTHFR_C.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF12225; DUF5981; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000060778}.
FT DOMAIN 13..55
FT /note="Methylene-tetrahydrofolate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12225"
SQ SEQUENCE 345 AA; 38490 MW; EF427D39683A7099 CRC64;
MNTGVVGKEV RELCPKRMLN GPCGGIRGEL CEVDDFQCPF YKAFENLRSA NYLKPLLDKG
FKVECEPGDV ELSGYAKMLE EGGPVLSTEV EPWSLKDVQF FETLKDKYHA FNVTDNPFGK
PHVSSVAVSI ELKRRGMEVI AQLTTRSRTR EALASDLMSL NAFGVTNVLA LTGDWAPHSV
FDLDAVRLVC LISLMNKGLL WDGSEIEPTT LVPGVASNPY FKYEKERLLR KARAGAVFAQ
TQPIFTSEIV RSLKEYPVTT VPSLLISTSR KVVRSLKEKG VKVPKEYEEG LIKSKAEGKA
DEFVLEYNLK LAEEILSKEL KGIHVMAPGR WDLLVKFGNA LRELL
//
