ID   A0A0U3HGT1_9MICC        Unreviewed;       300 AA.
AC   A0A0U3HGT1;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=NAD-dependent deacetylase {ECO:0000313|EMBL:ALU40377.1};
DE   SubName: Full=NAD-dependent protein deacetylase {ECO:0000313|EMBL:GEO93783.1};
GN   Name=cobB_2 {ECO:0000313|EMBL:GEO93783.1};
GN   ORFNames=AS188_12120 {ECO:0000313|EMBL:ALU40377.1}, KFL01_30890
GN   {ECO:0000313|EMBL:GEO93783.1};
OS   Kocuria flava.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Kocuria.
OX   NCBI_TaxID=446860 {ECO:0000313|EMBL:ALU40377.1, ECO:0000313|Proteomes:UP000057181};
RN   [1] {ECO:0000313|EMBL:ALU40377.1, ECO:0000313|Proteomes:UP000057181}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HO-9041 {ECO:0000313|EMBL:ALU40377.1,
RC   ECO:0000313|Proteomes:UP000057181};
RA   Zhou M., Dai J.;
RT   "Complete Genome Sequence of Kocuria flava strain HO-9041.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GEO93783.1, ECO:0000313|Proteomes:UP000321155}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 107626 {ECO:0000313|EMBL:GEO93783.1,
RC   ECO:0000313|Proteomes:UP000321155};
RA   Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT   "Whole genome shotgun sequence of Kocuria flava NBRC 107626.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP013254; ALU40377.1; -; Genomic_DNA.
DR   EMBL; BJZR01000185; GEO93783.1; -; Genomic_DNA.
DR   RefSeq; WP_058859067.1; NZ_CP013254.1.
DR   AlphaFoldDB; A0A0U3HGT1; -.
DR   STRING; 446860.AS188_12120; -.
DR   KEGG; kfv:AS188_12120; -.
DR   OrthoDB; 9800582at2; -.
DR   Proteomes; UP000057181; Chromosome.
DR   Proteomes; UP000321155; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR11085:SF2; NAD-DEPENDENT PROTEIN LIPOAMIDASE SIRTUIN-4, MITOCHONDRIAL; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU00236}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000057181};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00236}.
FT   DOMAIN          22..300
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        140
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         148
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         151
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         202
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         205
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ   SEQUENCE   300 AA;  32345 MW;  0DF45732874B2211 CRC64;
     MRTLRTGYGR PEVPDQFPDP DAADLGTGLP AAVDLLRGRR TAVLTGAGIS TDSGIPDYRG
     PGAAPRTPMT YQDFLSSPAR RSHYWARNQY GWRHLAEARP NPGHTVLARL EERGVVTGVV
     TQNIDRLHQA AGSVNVVDLH GRYSVVRCLQ CATRIPRAVL SDVLDELNPG FYDSLSSPED
     IEFAPDADAV ITETAGFRVP DCPVCDGILK PDVVFFGENA PRHRVLRALR MVDAAEALLV
     VGSSLTVNSG RRFVRHAVRA GRPVLIANHG RTRADGSARV KIDARAGEFL TALEAALGAA
//