ID A0A0U3NJB8_9ACTN Unreviewed; 332 AA.
AC A0A0U3NJB8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=UmuC domain-containing protein {ECO:0000259|PROSITE:PS50173};
GN ORFNames=AS200_04450 {ECO:0000313|EMBL:ALV31387.1};
OS Streptomyces sp. CdTB01.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1725411 {ECO:0000313|EMBL:ALV31387.1, ECO:0000313|Proteomes:UP000068029};
RN [1] {ECO:0000313|EMBL:ALV31387.1, ECO:0000313|Proteomes:UP000068029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CdTB01 {ECO:0000313|EMBL:ALV31387.1,
RC ECO:0000313|Proteomes:UP000068029};
RA Tian Y., Zhou G., Yang H., Lu X.;
RT "Complete genome sequence of the Streptomyces sp. strain CdTB01, a
RT bacterium tolerant to cadmium.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; CP013743; ALV31387.1; -; Genomic_DNA.
DR RefSeq; WP_058921073.1; NZ_CP013743.1.
DR AlphaFoldDB; A0A0U3NJB8; -.
DR STRING; 1725411.AS200_04450; -.
DR KEGG; scx:AS200_04450; -.
DR OrthoDB; 4317601at2; -.
DR Proteomes; UP000068029; Chromosome.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProt.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000068029}.
FT DOMAIN 25..128
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 332 AA; 35686 MW; C5C5BDE8D2376739 CRC64;
MTRAHEVSTV MHVRCPDGLG EEGYRQVLEQ LAELSPVVRA LPPGAALVEL RGALRYHGAD
ARRLGEVLRV RTLSRLGVDI RVGIGPTITV AATASARVPR PGGVLAVDPD QVASWLGPLP
VEALHGIGPR QADVLHDYGI HSVGLLAAVE PATVQRLLGG KAGRTASDRA RGIDPRPVVP
RELPTTAAVS RAFDRHVLDG ADVRAALLEL VVRLGLLLRR RDQAARAVTL TLRFAGGTRW
EKTRRLAEPS AHDDDLRVLA YRLMDAAGLQ RGRLTGLALK GEDLVDAGEV ARQISLDDAR
EARLVAEEVV DRVREKYGPD VIGPAAVFRH AS
//
