ID A0A0U3P509_9MICC Unreviewed; 304 AA.
AC A0A0U3P509; A0A1H5LAR9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:ALV44271.1};
GN ORFNames=MB46_00825 {ECO:0000313|EMBL:ALV44271.1}, SAMN04489740_2376
GN {ECO:0000313|EMBL:SEE74050.1};
OS Arthrobacter alpinus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=656366 {ECO:0000313|EMBL:ALV44271.1, ECO:0000313|Proteomes:UP000055883};
RN [1] {ECO:0000313|EMBL:ALV44271.1, ECO:0000313|Proteomes:UP000055883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A3 {ECO:0000313|EMBL:ALV44271.1,
RC ECO:0000313|Proteomes:UP000055883};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SEE74050.1, ECO:0000313|Proteomes:UP000182725}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22274 {ECO:0000313|EMBL:SEE74050.1,
RC ECO:0000313|Proteomes:UP000182725};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid degradation. {ECO:0000256|ARBA:ARBA00005023}.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; CP013745; ALV44271.1; -; Genomic_DNA.
DR EMBL; FNTV01000001; SEE74050.1; -; Genomic_DNA.
DR RefSeq; WP_044572748.1; NZ_FNTV01000001.1.
DR AlphaFoldDB; A0A0U3P509; -.
DR STRING; 656366.AS189_18040; -.
DR KEGG; arw:MB46_00825; -.
DR eggNOG; COG2084; Bacteria.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000055883; Chromosome.
DR Proteomes; UP000182725; Unassembled WGS sequence.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0009083; P:branched-chain amino acid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR011548; HIBADH.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01692; HIBADH; 1.
DR PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Branched-chain amino acid catabolism {ECO:0000256|ARBA:ARBA00022456};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 4..159
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..291
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 304 AA; 30637 MW; 9711C8EB0BFD1680 CRC64;
MAVVAWIGLG NMGGPMTANL VKAGHTVRGF DLSSAALDAA VAKGVIPADS IADAVSGAAV
VFSMLPKGDH VRAVYFGDGG ILANAAKETL LIDSSTIDIE SAQAVHDAAA AAGFRFVDAP
VSGGMSGAAA GTLTFMIGGE SGAVADASAY IEPMAGNIIP TGAATTGQAA KICNNLMLFI
NLASTAEGAV LADRLGLDKQ VFWDIASVSS GDSWALRTWY PLAGVVPTSA ANNDFAPSFT
AELANKDIGL AIAAARSTDT PLEIGEHVQQ LFQRLIDEGQ GGKDCSQIVS LVDGSLKTPA
TAIG
//
