ID A0A0U3PV22_9ACTN Unreviewed; 755 AA.
AC A0A0U3PV22;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Peptidase M4 {ECO:0000313|EMBL:ALV31260.1};
GN ORFNames=AS200_03715 {ECO:0000313|EMBL:ALV31260.1};
OS Streptomyces sp. CdTB01.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1725411 {ECO:0000313|EMBL:ALV31260.1, ECO:0000313|Proteomes:UP000068029};
RN [1] {ECO:0000313|EMBL:ALV31260.1, ECO:0000313|Proteomes:UP000068029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CdTB01 {ECO:0000313|EMBL:ALV31260.1,
RC ECO:0000313|Proteomes:UP000068029};
RA Tian Y., Zhou G., Yang H., Lu X.;
RT "Complete genome sequence of the Streptomyces sp. strain CdTB01, a
RT bacterium tolerant to cadmium.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP013743; ALV31260.1; -; Genomic_DNA.
DR RefSeq; WP_058920946.1; NZ_CP013743.1.
DR AlphaFoldDB; A0A0U3PV22; -.
DR STRING; 1725411.AS200_03715; -.
DR KEGG; scx:AS200_03715; -.
DR OrthoDB; 291295at2; -.
DR Proteomes; UP000068029; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF05345; He_PIG; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF49313; Cadherin-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000068029};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..755
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006843177"
FT DOMAIN 629..755
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 367
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 454
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 755 AA; 78490 MW; CAF4E9F1EAE0BC76 CRC64;
MPLRPRALLR RRRATALALA SIGSLLSLAV AGHAGAAPAA PSPVKITAKP RAGALPASLT
PARRAALVKN AQSAAADTAR HLGLGSKEKL LVKDVIRDAD GTTHTRYERT YAGLPVLGGD
LVVHDKSGLL TVTKAHRGAL SVPSLRSKIS AAGAADRAEA ASKRAEVTGS ETGKKPRRVV
WAATGKPVLA WESVVEGVQP DGTPSELQVV TDARTGKQLL AAQKVETGTG TGQYVGTVPL
GTTPSGSTYQ LVDPDRAGHK TYDLNQGTSG TGTLFTDDND AWGDGLPSNR QTAGVDVAFG
AAATWDYYKD TYGRNGIRND GVAAYSRAHY GSNYVNAFWQ DSCFCMTYGD GSGNTHPLTA
LDVAAHEMSH GVTAATAGLN YSGESGGLNE ATSDIFAAAV EFYENLPADP GDYLVGEKID
INGDGTPLRY MDKPSKDGAS HDSWSSTLGS IDVHYSSGPA NHFFYLLSEG SGAKTVNGVS
YDSPTYDGRP VTGIGIQNAA AIWYRALTTY MTSTTDYAGA RTATLSAAAD LFGAYSPTYL
AVADAWAAIN VGNRVALGVN LAPVGDQTSG IGQAVSLQVD AYTTNTAASL TYEATGLPDG
LSISPSGLIT GTPTTLGTSD VTIKVTDSTG ASASKTFTWR IAYVYANAAR VDIPDNGPAV
ESPVTITGRD GNASATTSVY VNIVHTYRGD LTVDLVGPNG TVYSLLDRSG GSADNVDQAF
TVDASAQPLN GTWKLRVQDR ASIDVGYIAR WQLTP
//
