ID A0A0U3SD26_9BACT Unreviewed; 492 AA.
AC A0A0U3SD26;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=AUC43_02405 {ECO:0000313|EMBL:ALW84052.1};
OS Hymenobacter sedentarius.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1411621 {ECO:0000313|EMBL:ALW84052.1, ECO:0000313|Proteomes:UP000059542};
RN [1] {ECO:0000313|EMBL:ALW84052.1, ECO:0000313|Proteomes:UP000059542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG5B {ECO:0000313|EMBL:ALW84052.1,
RC ECO:0000313|Proteomes:UP000059542};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP013909; ALW84052.1; -; Genomic_DNA.
DR RefSeq; WP_068189437.1; NZ_CP013909.1.
DR AlphaFoldDB; A0A0U3SD26; -.
DR STRING; 1411621.AUC43_02405; -.
DR REBASE; 137004; M.Hsp5BORF2405P.
DR KEGG; hyg:AUC43_02405; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000059542; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF4; TYPE I RESTRICTION ENZYME ECOKI METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ALW84052.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000059542};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ALW84052.1}.
FT DOMAIN 13..117
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 129..423
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 492 AA; 54590 MW; 3F0BDC18C1AC507A CRC64;
MRQPTPNATA QSLVQRVWGY ATVLRDDGVG YGDYVEQITY LLFLKMADEQ AGAPNAPAVP
EGKDWASLRH LEGDALEVQY RHLLTDLGKE PGMLGVIFKK AQNKIQNPAR LKHLLALIDR
ENWSGLGFDV KGEIYEGLLQ KNAEDVKGGA GQYFTPRPLI QAIVEAVAPA PGQTICDPAC
GTAGFLLVAR DYLVDTYGKD LDREQLRFLR DHTFHGTDIV DSVVRLAAMN LYLHGVGSTE
SPVQNRDSLL SDPGERYDFI LANPPFGKKS SITVMSEEGQ TSKDTLSYER TDFVATTSNK
QLNFVQHIYT ILKVGGTAAV VLPDNVLFEG GAGETIRRKL LQDCNVHTLL RLPTGIFYAQ
GVKANVIFFE KRAAAEQAQT KELWVYDLRT NQHFTPKGNP LTLAHLQDFI ACYGKPGQRA
QRQETEQFHR YELAQLLARD KVNLDIFWLK DDALEDSATL PAPDVLALEI TENLQAALAQ
FASIAEELEA TE
//
