ID A0A0U3T2W1_9ACTN Unreviewed; 587 AA.
AC A0A0U3T2W1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Penicillin-binding protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AERYTH_10585 {ECO:0000313|EMBL:ALX05114.1};
OS Aeromicrobium erythreum.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=2041 {ECO:0000313|EMBL:ALX05114.1, ECO:0000313|Proteomes:UP000067689};
RN [1] {ECO:0000313|EMBL:ALX05114.1, ECO:0000313|Proteomes:UP000067689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR18 {ECO:0000313|EMBL:ALX05114.1,
RC ECO:0000313|Proteomes:UP000067689};
RX PubMed=1883712;
RA Miller E.S., Woese C.R., Brenner S.;
RT "Description of the erythromycin-producing bacterium Arthrobacter sp.
RT strain NRRL B-3381 as Aeromicrobium erythreum gen. nov., sp. nov.";
RL Int. J. Syst. Bacteriol. 41:363-368(1991).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP011502; ALX05114.1; -; Genomic_DNA.
DR RefSeq; WP_067858290.1; NZ_CP011502.1.
DR AlphaFoldDB; A0A0U3T2W1; -.
DR STRING; 2041.AERYTH_10585; -.
DR KEGG; aer:AERYTH_10585; -.
DR PATRIC; fig|2041.4.peg.2214; -.
DR OrthoDB; 9789078at2; -.
DR Proteomes; UP000067689; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000067689};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 54..212
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 256..564
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 587 AA; 62681 MW; FF7080E08E68EB39 CRC64;
MKRQRLSRTR LRVSLLLVVS LFMLFGVRLF WIQGLDAQAY AAMARNASTQ PVTVPAPRGD
ILDRNGEVIA TSVDSLTLTA DPTLTTKKAP QIARILVSSL GEDRVDYFDL IEKLRTPDTR
FVVLEKNLPA AKGQKALQAL RKAGAAGVFS QKTTMRTYPG GRLAANLVGY MSQTKDSDTP
VGVQGIERQY DALLTGKDGS ATYEVSPTGQ RIPMADSTVV PMKPGQDVQT TIDRDLQWYA
DQRLADAVRS AGADWGLAIT MDVRTGQVVQ LSQAPTFDPG SKATMQDSNT VSRFVQTVYE
PGSVLKTITM AALADQGKIT PDTQISVPGK MVIDKFPIGD YWQHGTLNLT AAGVIAKSSN
LGTIVAAQQM SNQTMHDYLR KFGFGVGSGV QLPGESRGIL APAASWTKAN HATISFGQGI
SVTALQVVRA VGAIANGGVM VDPSVVSGFV DADGHRTDAK EVPSRRVVSK KAAAEVTRMM
EAVTADDGTA PAAQIPGYRV AGKTGTAWRV NPVTGRYVRG QNTVSFIGFA PADEPRFITY
VVLDKPFANA GGGSTAAPVF HDIMSMALER FGVAPTGSRS PKVAQEW
//
