ID A0A0U4C2F4_9ACTN Unreviewed; 579 AA.
AC A0A0U4C2F4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Endonuclease {ECO:0000313|EMBL:ALX05135.1};
GN ORFNames=AERYTH_10700 {ECO:0000313|EMBL:ALX05135.1};
OS Aeromicrobium erythreum.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=2041 {ECO:0000313|EMBL:ALX05135.1, ECO:0000313|Proteomes:UP000067689};
RN [1] {ECO:0000313|EMBL:ALX05135.1, ECO:0000313|Proteomes:UP000067689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR18 {ECO:0000313|EMBL:ALX05135.1,
RC ECO:0000313|Proteomes:UP000067689};
RX PubMed=1883712;
RA Miller E.S., Woese C.R., Brenner S.;
RT "Description of the erythromycin-producing bacterium Arthrobacter sp.
RT strain NRRL B-3381 as Aeromicrobium erythreum gen. nov., sp. nov.";
RL Int. J. Syst. Bacteriol. 41:363-368(1991).
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DR EMBL; CP011502; ALX05135.1; -; Genomic_DNA.
DR RefSeq; WP_067858354.1; NZ_CP011502.1.
DR AlphaFoldDB; A0A0U4C2F4; -.
DR STRING; 2041.AERYTH_10700; -.
DR KEGG; aer:AERYTH_10700; -.
DR PATRIC; fig|2041.4.peg.2237; -.
DR Proteomes; UP000067689; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF02151; UVR; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:ALX05135.1};
KW Hydrolase {ECO:0000313|EMBL:ALX05135.1};
KW Nuclease {ECO:0000313|EMBL:ALX05135.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000067689}.
FT DOMAIN 227..305
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 415..450
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
SQ SEQUENCE 579 AA; 63554 MW; CE53503AD95B2FD4 CRC64;
MTSQPTRPVH HQASFEELGR PLSDVTFCVV DLETTGGSPK AGARITEIGA VKVRGGEVLG
ELQTLVNPEE SIPAFITVLT GITDAMVVQA PRIAEALPSF LELAAGSVLV AHNAPFDVGF
LKHNARELGI PWPRFEVLDT AVLARRALLR EEVRNVKLST LAAHFGAGTT PDHRALHDAR
ATVDVLHGLF ERLGSLGVHT LEDAVTFTSK VTPEQRRKRH LAQHLPHEPG VYLFRDARDD
VLYVGTSRDL RKRVGSYFTA AETRTRMGEM VKLAERVDAV VCATALEARV RELRLIAAHR
PPYNRRSRFP ERQSWIKLTR EPWPRLSMVR RVLDDDAVYV GPFGHRSQGE LALAALHETF
QVRQCTTRMG RRPRGSTCAL ADLGRCLAPC TGDLDPDVYA TEVARLDAAL TGDPAEVVER
LRARMGELGA QQRYEEAAQV RDRLAASLRA VDRTQRLRQL TDVAELVAAA PAEKGWEVHV
VRHGRLAAAG LLPRHVHPAA WVDTLLATAE DVPTPGNGTH PAPAASVEET ETLLRWLESP
GVRMVRGSWQ VPTAGAARHV AALPTESDDQ RATRSRLSA
//
