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Database: UniProt
Entry: A0A0U4W5T1_9GAMM
LinkDB: A0A0U4W5T1_9GAMM
Original site: A0A0U4W5T1_9GAMM 
ID   A0A0U4W5T1_9GAMM        Unreviewed;       450 AA.
AC   A0A0U4W5T1;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   28-MAR-2018, entry version 16.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN   ECO:0000313|EMBL:ALZ77229.1};
GN   ORFNames=ATY27_16685 {ECO:0000313|EMBL:ALZ77229.1};
OS   Rheinheimera sp. F8.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Chromatiaceae; Rheinheimera.
OX   NCBI_TaxID=1763998 {ECO:0000313|EMBL:ALZ77229.1, ECO:0000313|Proteomes:UP000059499};
RN   [1] {ECO:0000313|Proteomes:UP000059499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F8 {ECO:0000313|Proteomes:UP000059499};
RA   Schuster A.K., Szewzyk U.;
RT   "Draft genome sequence of Rheinheimera sp. F8, a biofilm-forming
RT   strain which produces large amounts of extracellular DNA.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|SAAS:SAAS00984457}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CP013656; ALZ77229.1; -; Genomic_DNA.
DR   EnsemblBacteria; ALZ77229; ALZ77229; ATY27_16685.
DR   Proteomes; UP000059499; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000059499};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000059499}.
FT   DOMAIN       14    106       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      130    441       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      313    355       {ECO:0000256|SAM:Coils}.
FT   COILED      359    379       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   450 AA;  50754 MW;  0628BEB89DB91D99 CRC64;
     MNHTQNPSTN PEIYTVSRLN AEVRLTLELQ FRQLWLCGEI SNFVAASSGH WYFSLKDAAA
     QVKVAMFKQA NRNAAFVPRN GQQVLIRARI SVYEPRGEYQ LLVDFIEPAG DGLLRQQYEM
     LKAKLTAEGL FAPERKKQLP SQVQRIGVIT SPTGAAVRDI LTVLARRAPA LEVIIYPALV
     QGAQAAQDLQ AALAHAIRRN EVDVLIIGRG GGSLEDLYCF NDEQLARQIA HCPLPIVSAV
     GHEIDFTIAD FVADVRAATP SAAAELVSPD QQHQLTQLIQ LQQRLQRGIR LQLGQQAQWF
     LQQHSKLQLL HPKRRLEQQQ QRLDELQLRL QRAGQQQLER KERQLEQHQQ RLLQHAPRAA
     VLQQHATALQ ERLQRAMQQQ LQTLTQQWQQ HSALLHQVSP LATLNRGYSL TFTAENTLVK
     SVQQLKSGDA LTVRFADGHV VTEVKQIQAN
//
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