ID A0A0U5BHZ0_9MICO Unreviewed; 276 AA.
AC A0A0U5BHZ0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN ORFNames=MalAC0309_0282 {ECO:0000313|EMBL:BAU31157.1};
OS Microcella alkaliphila.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microcella.
OX NCBI_TaxID=279828 {ECO:0000313|EMBL:BAU31157.1, ECO:0000313|Proteomes:UP000218965};
RN [1] {ECO:0000313|Proteomes:UP000218965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAM AC0309 {ECO:0000313|Proteomes:UP000218965};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAU31157.1, ECO:0000313|Proteomes:UP000218965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAM AC0309 {ECO:0000313|EMBL:BAU31157.1,
RC ECO:0000313|Proteomes:UP000218965};
RA Kurata A., Hirose Y., Kishimoto N., Kobayashi T.;
RT "Microcella alkaliphila JAM AC0309 whole genome shotgun sequence.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC ChEBI:CHEBI:57845; EC=4.2.1.75;
CC Evidence={ECO:0000256|ARBA:ARBA00000783,
CC ECO:0000256|RuleBase:RU366031};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
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DR EMBL; AP017315; BAU31157.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0U5BHZ0; -.
DR KEGG; malk:MalAC0309_0282; -.
DR OrthoDB; 9815856at2; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000218965; Chromosome.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW ECO:0000256|RuleBase:RU366031}.
FT DOMAIN 41..257
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 276 AA; 29122 MW; 1BAFF8CDA0FACA6F CRC64;
MSSLRDGTTI ERTPTAALPV IKPLLGWRVL VPRGGKWGDG IAAQLRSFGA QPVIAPLINF
ARPEDPALLT AALGRLRDGH YDWLLVTSAT TVDVLVGHGV RPPESTRIAA VGETTAQALQ
LAGYRVDFVP SDHSARGLLK EWPGGSGLRA LLPQSEIAEQ VLLQGLLERG VDAEFVAAYR
TVGVGAPPEV IADVAGRRIR AILVSSGSVA RQIAAQFSPL PSEAVVVCIG PRTAFDARAA
GLTVHRIAEE RSSASLVRAL AEFAIDPHDA HPPMVS
//
