ID A0A0U5H3T3_9EURY Unreviewed; 703 AA.
AC A0A0U5H3T3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Formate dehydrogenase alpha subunit {ECO:0000313|EMBL:CQH58238.1};
DE EC=1.2.1.2 {ECO:0000313|EMBL:CQH58238.1};
GN Name=fdhA {ECO:0000313|EMBL:CQH58238.1};
GN ORFNames=HHUB_2705 {ECO:0000313|EMBL:CQH58238.1};
OS Halobacterium hubeiense.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=1407499 {ECO:0000313|EMBL:CQH58238.1, ECO:0000313|Proteomes:UP000066737};
RN [1] {ECO:0000313|Proteomes:UP000066737}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JI20-1 {ECO:0000313|Proteomes:UP000066737};
RX PubMed=26628271; DOI=10.1111/1462-2920.13130;
RA Jaakkola S.T., Pfeiffer F., Ravantti J.J., Guo Q., Liu Y., Chen X., Ma H.,
RA Yang C., Oksanen H.M., Bamford D.H.;
RT "The complete genome of a viable archaeum isolated from 123-million-year-
RT old rock salt.";
RL Environ. Microbiol. 18:565-579(2016).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN831302; CQH58238.1; -; Genomic_DNA.
DR RefSeq; WP_059057129.1; NZ_LN831302.1.
DR AlphaFoldDB; A0A0U5H3T3; -.
DR STRING; 1407499.HHUB_2705; -.
DR GeneID; 26659336; -.
DR KEGG; hhb:Hhub_2705; -.
DR OrthoDB; 23466at2157; -.
DR Proteomes; UP000066737; Chromosome I.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR PIRSF; PIRSF000144; CbbBc; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:CQH58238.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000066737}.
FT DOMAIN 4..61
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 703 AA; 76989 MW; C3147A650888C41A CRC64;
MSTDESTKTI CPYCGVGCGI SVRQGDEPGD VSFAPWGEAP VNEGRVCIKG GAATEVVDHE
DRLTEPMIRE DGDLRPASWD EALSRVVAEM EDIRDEHGPD GMGFYASSKT MNEENYLLQK
LARRFGTNNV DNCTRMCHAS TVYALRESLG AGAMTNSMAD LRDEADVFWI QGANPGEQHP
IANSQYFRQA VLDGATVIQV DPHANKTTES FEIEESDRHM HLQLEPGTDI PLLNAVLKTV
LDNGWVDEEF VAERTEGIED LRETLADFDK EAAAEECGVP LEDIERAAEA YATADNAAIF
TGMGMSQHAC GVDNVQNEIN LALATGNLGR PGTGVNPLRG QNNVQGASDV GAMPNVLPGY
QPVDDDEARE AVEDVWGFEI PSEPGLTNVE ITHSVGDTVH GLYVMGENPV MSEPNADRVA
DLLDETEFVV VQDIFPTETV EYADVVLPAT TWAERGGTVT NTDRRVQRMR GVEKVHEDTR
HDLDILTEVG TRLFGEDAGF DFDGPEEVFE ELREVCPIYH GMTYDALGEE GLHWPCYEPG
DEGDQFLYAD SFDTPSGRGQ IEGVRHQPPR ETPDDEYPLI LTTARLEEHY NTGTMSRRSA
TLSRQHPENF VDVHPEDAER FGVADGDSVT LRSRRGEITL RANVTEAIKE GVVWTTPHFA
DASANVLTND VLDERAKIPE YKAAAVDVTL ADGGADPDAP ADD
//
