ID A0A0U5JAU2_9BACT Unreviewed; 325 AA.
AC A0A0U5JAU2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Putative malate dehydrogenase {ECO:0000313|EMBL:CUI17161.1};
DE EC=1.1.1.37 {ECO:0000313|EMBL:CUI17161.1};
GN Name=mdh3 {ECO:0000313|EMBL:CUI17161.1};
GN ORFNames=PNK_1551 {ECO:0000313|EMBL:CUI17161.1};
OS Candidatus Protochlamydia naegleriophila.
OC Bacteria; Chlamydiota; Chlamydiia; Parachlamydiales; Parachlamydiaceae;
OC Protochlamydia.
OX NCBI_TaxID=389348 {ECO:0000313|EMBL:CUI17161.1, ECO:0000313|Proteomes:UP000069902};
RN [1] {ECO:0000313|Proteomes:UP000069902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KNic {ECO:0000313|Proteomes:UP000069902};
RA Bertelli C.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC {ECO:0000256|ARBA:ARBA00009613}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN879502; CUI17161.1; -; Genomic_DNA.
DR RefSeq; WP_059061305.1; NZ_LN879502.1.
DR AlphaFoldDB; A0A0U5JAU2; -.
DR STRING; 389348.PNK_1551; -.
DR KEGG; pnl:PNK_1551; -.
DR PATRIC; fig|389348.3.peg.1738; -.
DR InParanoid; A0A0U5JAU2; -.
DR Proteomes; UP000069902; Chromosome cPNK.
DR GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23382; MALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23382:SF0; MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|PIRSR:PIRSR000102-3};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003369,
KW ECO:0000313|EMBL:CUI17161.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000069902}.
FT DOMAIN 6..152
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 157..319
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT ACT_SITE 187
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
FT BINDING 11..17
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT BINDING 105
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT BINDING 129..131
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
SQ SEQUENCE 325 AA; 36305 MW; 048A230BC60EC91E CRC64;
MIAPKKVVIT GASGRIGYQL VFLIAQGLLL GADQPIILCM LEKESNQQKC RGIQMELEDS
IFPLLRAVHY THDLDCAFTG ADYVFFCGAK TCHDPKTRAL VQAENWEALT LQGETINRVC
SHQTLFLMVA NPCNTNTLAL IKAAPNIPPM NFHSMMRLDL NRARQFIAEK AQCLSQDVEH
MLIWGNHSPR VVPDWSHVKI MASPISLLVD NNWLSSHFIH AVQKRGMAIT QNMGLSSCAS
AAYAAIEAMK ALIVPTAQNS FFCTGMYSSS NPFEFDQDLV FGLPCRTITR GVYEICEDYS
PHPLLKELIK CSEAELLEER ARLKK
//
