ID   A0A0U5JCN2_9BACT        Unreviewed;       387 AA.
AC   A0A0U5JCN2;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Cystathionine beta-lyase {ECO:0000313|EMBL:CUI16143.1};
DE            EC=4.4.1.8 {ECO:0000313|EMBL:CUI16143.1};
GN   Name=metC {ECO:0000313|EMBL:CUI16143.1};
GN   ORFNames=PNK_0515 {ECO:0000313|EMBL:CUI16143.1};
OS   Candidatus Protochlamydia naegleriophila.
OC   Bacteria; Chlamydiota; Chlamydiia; Parachlamydiales; Parachlamydiaceae;
OC   Protochlamydia.
OX   NCBI_TaxID=389348 {ECO:0000313|EMBL:CUI16143.1, ECO:0000313|Proteomes:UP000069902};
RN   [1] {ECO:0000313|Proteomes:UP000069902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KNic {ECO:0000313|Proteomes:UP000069902};
RA   Bertelli C.;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; LN879502; CUI16143.1; -; Genomic_DNA.
DR   RefSeq; WP_059060109.1; NZ_LN879502.1.
DR   AlphaFoldDB; A0A0U5JCN2; -.
DR   STRING; 389348.PNK_0515; -.
DR   KEGG; pnl:PNK_0515; -.
DR   PATRIC; fig|389348.3.peg.567; -.
DR   InParanoid; A0A0U5JCN2; -.
DR   Proteomes; UP000069902; Chromosome cPNK.
DR   GO; GO:0004121; F:cystathionine beta-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:CUI16143.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000069902}.
FT   MOD_RES         203
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   387 AA;  42320 MW;  AA6BC405A7156BB0 CRC64;
     MKKETGQYDI ATRAIHAGQE PDPTTGAIMT PIYATSTYVQ ESPGKHKGYE YSRTGNPTRA
     AYERCVADLE GGACGLAFAS GLAAIATVLE VLQPGDHVIV CDDVYGGTYR LFEKVRKRSA
     GLQTTFVDLS LPDLVEAAIQ PNTRMIWVET PTNPMLKLIN LQQIAVLARK HKLIAVADNT
     FATPMIHQPL AYGFHIVVHS ATKYLGGHSD IIGGIVVVGE DAALVEQLKF LQNAVGAIAS
     PFDSFLALRG IKTLALRMER HCSQAMELAG WLEKHPKVEK VMYPGLLSHP QYQLAKEQMH
     YYGGMISVQL KCDLAETLHV LERCQLFALA ESLGGVESLI EHPALMTHAS IPREQRERLG
     IKDGLIRLSV GVEAVADLRS DLDQALK
//