ID A0A0U5NR90_9CLOT Unreviewed; 578 AA.
AC A0A0U5NR90;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Sugar fermentation stimulation protein homolog {ECO:0000256|HAMAP-Rule:MF_00095};
GN Name=yfhQ {ECO:0000313|EMBL:CUX23502.1};
GN Synonyms=sfsA {ECO:0000256|HAMAP-Rule:MF_00095};
GN ORFNames=BN3456_00672 {ECO:0000313|EMBL:CUX23502.1};
OS Clostridium sp. C105KSO13.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1776045 {ECO:0000313|EMBL:CUX23502.1, ECO:0000313|Proteomes:UP000198973};
RN [1] {ECO:0000313|EMBL:CUX23502.1, ECO:0000313|Proteomes:UP000198973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C105KSO131 {ECO:0000313|EMBL:CUX23502.1};
RA McClelland M., Jain A., Saraogi P., Mendelson R., Westerman R.,
RA SanMiguel P., Csonka L.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8-
CC oxoguanine:adenine mismatched double-stranded DNA, leaving an
CC apurinic site.; EC=3.2.2.31;
CC Evidence={ECO:0000256|ARBA:ARBA00000843};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the Nth/MutY family.
CC {ECO:0000256|ARBA:ARBA00008343}.
CC -!- SIMILARITY: Belongs to the SfsA family. {ECO:0000256|HAMAP-
CC Rule:MF_00095}.
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DR EMBL; FBWL01000151; CUX23502.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0U5NR90; -.
DR STRING; 1776045.BN3456_00672; -.
DR OrthoDB; 9802365at2; -.
DR Proteomes; UP000198973; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000701; F:purine-specific mismatch base pair DNA N-glycosylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd03431; DNA_Glycosylase_C; 1.
DR CDD; cd00056; ENDO3c; 1.
DR CDD; cd22359; SfsA-like_bacterial; 1.
DR Gene3D; 2.40.50.580; -; 1.
DR Gene3D; 3.40.1350.60; -; 1.
DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR HAMAP; MF_00095; SfsA; 1.
DR InterPro; IPR005760; A/G_AdeGlyc_MutY.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR003265; HhH-GPD_domain.
DR InterPro; IPR023170; HhH_base_excis_C.
DR InterPro; IPR000445; HhH_motif.
DR InterPro; IPR044298; MIG/MutY.
DR InterPro; IPR029119; MutY_C.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR005224; SfsA.
DR InterPro; IPR040452; SfsA_C.
DR InterPro; IPR041465; SfsA_N.
DR NCBIfam; TIGR01084; mutY; 1.
DR NCBIfam; TIGR00230; sfsA; 1.
DR PANTHER; PTHR42944; ADENINE DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR42944:SF1; ADENINE DNA GLYCOSYLASE; 1.
DR Pfam; PF00633; HHH; 1.
DR Pfam; PF00730; HhH-GPD; 1.
DR Pfam; PF14815; NUDIX_4; 1.
DR Pfam; PF03749; SfsA; 1.
DR Pfam; PF17746; SfsA_N; 1.
DR SMART; SM00478; ENDO3c; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR SUPFAM; SSF55811; Nudix; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:CUX23502.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CUX23502.1};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000198973}.
FT DOMAIN 266..417
FT /note="HhH-GPD"
FT /evidence="ECO:0000259|SMART:SM00478"
SQ SEQUENCE 578 AA; 65370 MW; 8B703B8E55CDBFCD CRC64;
MKYERIEKAI FLERPNRFIA YAKLNGKREI IHVKNTGRCA ELLIPGAVIY VQRSDNPARK
TGWDLIAVEK GARLINMDSQ IPNKVVQEWI EAGNLFGHEP YVRPETTYKN SRFDFYVEAQ
GRKIFVEVKG VTLEENRVVR FPDAPSERAV KHVEELGSAV KEGYGAYVIF VVQMKGVRYF
TPNVDTHPAF GEALKKARKA GVRVLAYDCN VTSDSIELNQ AVPVVLGSPI LKEAADPVVS
WYRTNKRDLP WRHDTSAYHI WVSEIMLQQT KVEAVKPYYE RFLKELPTVS DLAEIQEDKL
LKLWEGLGYY NRVRNMQKAA RQIMIDYQGE FPHTYEEIRS LKGIGNYTAG AVSSFAYGMA
KAAVDGNVLR VVSRLTASPD DIMKAGVRTR IEAEVEEVIP PAAASDFNQG LIELGAMVCL
PGRGPKCEEC PVAHLCRARL LGIEKELPVR TKPKARKIEK RTVLILKDEN TVAIKKRPSK
GLLAGLYELP NLEGHLNKKE VIEYCHSIGL SPLHIKKTKG AKHVFSHIEW HMIGYEIKID
ELEKNCSSNM IFAPRSEIEE KYSIPSAFEA YRGAALKQ
//
