ID A0A0V0QBB7_PSEPJ Unreviewed; 4253 AA.
AC A0A0V0QBB7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=p-loop containing nucleoside triphosphate hydrolase {ECO:0000313|EMBL:KRW99533.1};
GN ORFNames=PPERSA_02391 {ECO:0000313|EMBL:KRW99533.1};
OS Pseudocohnilembus persalinus (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC Pseudocohnilembus.
OX NCBI_TaxID=266149 {ECO:0000313|EMBL:KRW99533.1, ECO:0000313|Proteomes:UP000054937};
RN [1] {ECO:0000313|EMBL:KRW99533.1, ECO:0000313|Proteomes:UP000054937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36N120E {ECO:0000313|EMBL:KRW99533.1};
RX PubMed=26486372; DOI=10.1038/srep15470;
RA Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C., Yuan D.,
RA Miao W.;
RT "Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus
RT persalinus provides insight into its virulence through horizontal gene
RT transfer.";
RL Sci. Rep. 5:15470-15470(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRW99533.1}.
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DR EMBL; LDAU01000210; KRW99533.1; -; Genomic_DNA.
DR EnsemblProtists; KRW99533; KRW99533; PPERSA_02391.
DR InParanoid; A0A0V0QBB7; -.
DR OMA; RFMMVGG; -.
DR OrthoDB; 176993at2759; -.
DR Proteomes; UP000054937; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Hydrolase {ECO:0000313|EMBL:KRW99533.1};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054937}.
FT DOMAIN 952..1384
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1524..1849
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2015..2160
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2387..2473
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2542..2788
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2804..3149
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3179..3409
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3654..3767
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3799..3937
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3945..4248
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 54..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 863..938
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1115..1142
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2831..2862
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3031..3118
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3357..3384
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 116..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4253 AA; 493805 MW; 4232246905D40E96 CRC64;
MEEGTQNENM YAYEEQSQFP NFTASIRNSL NQTKLPRHNR VKHAPLLKSL KSDLQYQQDQ
PQTQQDLSQT QQPAKTYKQF TKEIFELPKL KSNNNSLYSS MHQKAHSEVT TSKHKKDFSL
TLNPNLNPNP KKKTSERPLN QSLSLPKNPS HYMLNKSDDE EEITETIKFF PDKGLNANKR
LRNYDCYEEE LTPQFWVEKY KGTQPPHAAT PLYLNNHYTW TNVELLGYNE ATKKFQVKVL
DTGAVKEVVR LSILFKDEDA AAFKERVELS KQRQLNAEDE MRFQNYVDAQ KMDDISSMPK
ITNQKILNKV NNVVKFNHQL TDKDQINKIK IVKDQMSEAE FDYVRFMKKC IVLKQMQDPR
NEPKWLQYRI KNRFEKKTIP LLGTIEKIEI ENKMVNVSNL AKYHISKKAK IIYTLQQITG
RSQQYENHKL FQINWKPQDL PMQLSIYDQS QNNFHFTEKT QLSMQWREHI IATIYDNLKD
EYQFWAPDKS GYSSELKSLI TRIEFMFNHY MQQNVVKQNI DTYVKFIKDF IEPPKINHQE
GQIWSIQKKP LIIISLELNQ LKLQQIQKES TQKKDKKKDQ LQKQQQQEDP SNPNNEAIYF
KPSLKEIQET LQNPFSQLVK TCNSFLTLEK ELVPMVVSEQ GPAFPLSEDH EWIKMGKQVI
QEYVAKGFEE PQQILNQFAE FNFVIEKSAR QVLKEIFANL KDKHPVQYLD EQFTASCRHH
LKIYQQTKFR IQSVCIDNKD SRLFQIRTKN AKQLLIQQVD LVMQAIYERI GDIIDKNIKR
ILEEYKQLEN EISEKTPNDE EKWKKLVQVK SELDVNLDRL KIQCNIVRDY MNILEDFFQD
INNVSFTTYW GLKSFPPSIQ SIKGDARRTI EKYEEKLKTQ LQAEKDQFER SLVDLVKQFT
ELKNLNQFDK ATENYQVFNE LDEKINKSKE KCKNFNQREK IFKEPESAYA DLETLDKEYK
DYFGMWQTAY NFTTDSMGYL TNSLIQQDST SIEKNISSLY IQTKEYLKTF KNNDEDIAAD
VCTTLKEEIE KFKEYLFLFQ ALTTEAMRKN KARSYWEEIF ERCELKDNEK TGKEIEILQN
IEEITLSKLE DFGLKKNNPD HRLVVEDISR KATKQFDIEK KLKEMEEKLR GLQIDTQDYK
ATGTHVVKGI DELLQELDDQ LNALLMIKAS PFIKGNIINQ RSANQIENKI VLIQDTIEGA
IKCQRAWMYL EPIFASDDIK KKMEQETRYF GKVNNNFREA MSRFEKEKLV WDIIEGENMK
KMFLADNITL DEIQQSLSEY LETKRKYFPR FYFLSDEELL EILADTKDPL KVQKHIGKCF
EAIQQLKFEE GTSIISGMIS AEKEHVKFNR TIDVNEGNRK GNVEVWLLEI EKLMIETLIS
ITKDSLLDTQ TERTLWVQKW PGQVVLAVNM TRWTLGSEIA ITQGKNGTSP HYSNLTEYRE
YLENELKDIV ALVRQDLEDI TRLTLGALIV LDVHSKDTIQ ILEEERVESI QDFSWMSQLR
YYWTEPNQKE KILWVKMINA ELKYGFEYLG NSPRLVITPL TDRCYRTLMG AFHLYYGGAP
EGPAGTGKTE TTKDLAKATG VQCVVFNCSD QLNYLAMRKF FKGLASSGAW CCFDEFNRID
LEVLSVIAQQ VLTIQNAIKD KKKIFEFDGE DITLLPSCAI NITMNPGYAG RSELPDNLKA
LFRSCAMMVP DYALIAEIYL YSVGFEDARN LARKIVASLR LSSEQLSSQS HYDFGMRALK
AILTAGGNLK RVMDEVEDII CLRALMDVNL PKFTKNDVPL FTSITSDLFP GVKLPEIDYG
HLMNAIDKAC DEQNLQKLTS FKDKCIQLYD TINVRHGLMI VGNAGSGKTC VMETLQKAQT
SLKGIEKFQS TLILKLNPKS ISGDQLYGKL DPDTKQWTDG VVANIMRDCV NDVQNPEKKW
VVFDGPVDAI WIENMNTVLD DNKKLCLSSG EIIKLTNQMT MIFEVEDLAV ASPATVSRCG
MVFLEPDILG WEPLIDSFVQ TIPETIQNKK EHMTTILKWL FSVTLAWSYK FGKFLVHDME
QQIVLSGLKY INTFLQKYVQ QEDEKEIKLP KNIEDILSQI CLFGVIWSVG AALEETSRKT
FHELIQKMIS ASDDVNIQFK LEHEIPDYQP HTIHVKIPEK VKIFELSLQI NNDQPEWVNW
IQTQEKYIPP EGGSYHNLII PTSDSIRNNY FLNTCMEHKI HLLICGNTGT GKTVNIINQL
NTNYYNSEWT NLCTAFSGQT SANQVQHLIE SKVNQKRRKR VYGPEDGKKY IAIFIDDLNM
PQKEVFGCQP PIEILRQWMD TGGWYDLETK EKEFKILQGI TFVASMLPPT GGRNKVTNRF
IRHLNLLYVE PFENQSLQRI FTTALDWYFK KESISKNDII QLKEKIVNST IELYQKIQES
PDLLPTPAKS HYIYNLRDIS KVFQGISMAS VKSFQDESDF IKLWAHECQR VFQDRLINAQ
DQGIMQQMLN DIILNNFRRD WTSLVEVQPL LWANFVPTLM KDGDPAKRIS NVYCELTDRE
ILKKVCYEKL EEYNNFYIAS RMNLVLFDVA IQHIIKIVRV LQTSFGHCLL VGVGGSGRKS
LATLSSFIAD KEPYQVDQRN WEEELQKLMK NCGIDQKETV FLFSDTQIMK EQMVEDISNL
LNNGEVPNLF PNDEKMKIIE EFDEGTNNEK YSKFITECKN RLHLCLTFSP VGDDFRRRLR
TFPALVNCTT IDWFLPWPEE ALRNTAYSHF TQQMKFSDEK QVQGLVNIAV DMQQRITKLS
QRYLQELRKY YYVTPTSYLE LLDTFKSLKD KQEKLMQKYI NQYSSGVNKI QKTEEVVEQM
QEELNVKKPI LQAKQVENKK LLKTLKENEK KAQAEKDICD EEARECGLKR AAADTIRTDC
QGELDKVIPI LEAAQAALKK LNPKDIDEVK SFKSPSGGVI LTMQAVIIAF DETKQVPWKP
KPDGKPGEKI QDFWEYAKKK VLNGKLLSRL QGFNEDQILA IKNIEGLKEK CQNPDFETKA
VTSQSKAAGG ICFWVHSVVQ TSEALQVVIP KREELAKAEA ALKEAEEILQ EKQQNLQRVL
DNLAKLKADF DEADKEEKRL SQDYKDCERK LNNAQKLIDG LSSEKESWSE KAKNYKEDIK
SVVGDTLLAS GIIAYLGAFP IDYRAEVSEA WHKIFQENNI LYNPKFNLSN LSSEIEISKW
TNEQKLPNDQ FSIDNAIIKQ NSQRWPLMID PQQQANTWIK NMYKDLPDGQ FFILKPVDFV
PAKMKQLRAK IEACISNGFK ILYENISEYI EPIFESILQQ KYIMQGNQKV LKFDDKSVDY
NDDFQFIMTT KLARPHYPPE VCVKVTLLNF QVTQKGLQDN LLNFIMKKEY EHKVTAMDKA
IVDLNDSNKR QKELENKILD LLEKAGDNIL DSQELIDTLD SSKVETDQIK DTQMKSKKEK
DSFDTIRNTY TQVAKRISHL YFVILDLSNL EPTYQWSLEY YTNIFAMGIA KAQEMGKENK
MNNIIDQTQI LIYQNISMSL LVKDKLLYSF LLCIKILESE DIINQKIIRF MMVGGTWTES
PKPMPKSNFI SQKLWIQIQE MSHDLPEFKG FDDDFAANIA QWKQHFEHPE PYTLPLVGKW
EENLNNFQKL LVQRILFADK FTKAVQNLIQ HEMDERYINP PEFDLDQAFE GSTQLTPMIF
ILSVGADPRE EIEEFAKKQD MLQGFKPISL GQGQGEMAEK ALKSAAEEGT WVLFQNCHLA
PSFMPDLERI LESLNENNTH SNFRCWLTLM PSEKFPTQVL MKGIKMTYEP PSGLKANLER
VLNTQDPKSF EDCQKPQAWK KLYFGLSFFH ALILERRKFG PLGWNIPYSF TQSDFTISQS
QLKMFLNEFD EIPYEALNYM VAEANYGGRV TDDKDRRLIT VLLKDFYTPK ILNEDYKFSK
SGNYFAPQEG DLQSYRDYAS KLPRYDMTEV FGLHENAEIS SALLETDFIT SNILSLLPRT
VSGAGGASAE DMIKEKIDNL LSKLPPDFDT KEASRKHPII YEESMNTVLN QELIRFNKLL
KVVRSSLKDV KKAIDGLLVM SDELELVYDG IFDNKVPQSW HKIAYPSLKP MGSWIGNLVE
RLHFMQKWID EGAPSCFWIS GFFFTQSFLT GTLQNFARKH NVPIDTLIFK FQALDKDADT
SQPPQDGCYI HGLYFDGGRW DSENKVINES LPKVLYSDLP RIQLIPTQEK IKWSEHRDVY
ECPVYKTSRR AGTLTTTGHS TNFVMAMYLP IIEGTTPEHW IKRGLAALTQ LND
//
