ID   A0A0V0QWP6_PSEPJ        Unreviewed;      1295 AA.
AC   A0A0V0QWP6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   13-SEP-2023, entry version 25.
DE   RecName: Full=CSC1/OSCA1-like cytosolic domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PPERSA_13109 {ECO:0000313|EMBL:KRX06630.1};
OS   Pseudocohnilembus persalinus (Ciliate).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC   Pseudocohnilembus.
OX   NCBI_TaxID=266149 {ECO:0000313|EMBL:KRX06630.1, ECO:0000313|Proteomes:UP000054937};
RN   [1] {ECO:0000313|EMBL:KRX06630.1, ECO:0000313|Proteomes:UP000054937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=36N120E {ECO:0000313|EMBL:KRX06630.1};
RX   PubMed=26486372; DOI=10.1038/srep15470;
RA   Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C., Yuan D.,
RA   Miao W.;
RT   "Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus
RT   persalinus provides insight into its virulence through horizontal gene
RT   transfer.";
RL   Sci. Rep. 5:15470-15470(2015).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CDC45 family.
CC       {ECO:0000256|ARBA:ARBA00010727}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX06630.1}.
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DR   EMBL; LDAU01000094; KRX06630.1; -; Genomic_DNA.
DR   EnsemblProtists; KRX06630; KRX06630; PPERSA_13109.
DR   InParanoid; A0A0V0QWP6; -.
DR   OrthoDB; 1407079at2759; -.
DR   Proteomes; UP000054937; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   InterPro; IPR003874; CDC45.
DR   PANTHER; PTHR10507; CDC45-RELATED PROTEIN; 1.
DR   PANTHER; PTHR10507:SF0; CELL DIVISION CONTROL PROTEIN 45 HOMOLOG; 1.
DR   Pfam; PF02724; CDC45; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054937};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        638..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        824..845
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        857..878
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        905..925
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        945..968
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1013..1041
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1067..1088
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          117..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1245..1266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..142
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1295 AA;  151506 MW;  4706A5316E04E015 CRC64;
     MCKQDKTQIL KSEGVLFNVY PCQGYQHLEQ IIEDLKELEN LRSILFINCG ALIDLTQSWF
     AQNDRKIKAY ILDNHRPIQH ENILSERKII VVDDEISNLD NCPTQEDIQL YQNQLNEQDE
     NSSEGEFQFD NDEDDDQDEL ENQFGENLSI KNEKRKQSPN QFHKKKQKKL KIIQESEQKI
     QEYYEGYYYG IPTAYLSYQM SLICNKISSD QIWLGILGLT DMYLHQKLNE ENYLKIYLDI
     KSRLSQYGIY EQEFTDNHQN YEIGQIIPEN DYKFMLLKHW NLYDSIKYSN VIGPKLGIWN
     EKNKKGELES LIAKLGIPLE QAEQQYKFMD YKHKKQLKNK LVEVGDQFKL SDVLLINSFI
     RQIDQTVQIS ASDMVYCLQT VLECPKSILE KVFSEYQLQD KIQEQKQTNN NQNNNNNDQQ
     QNNDNQYSDD FIIDESRSRN FYWAVDLIKE AQNSRVKLIK EAINIAIDFQ KAMVNEATFL
     IERNAMESND NFRYCIIKKE QLQHQKFFQN PFSLQKLGMY IMEIYKYRKN EYNNMNQQKP
     IILACQQSKS ETYLVTGIIP IQLTDAYIKK KQYDPDESPP DIRKAKKHGQ AQRVCKDIDY
     TKYVKSKCEC CGKAIDNELL SMCDHPNNLQ HLGTTYPLYF VFIKQCFIMI AIHMCIQAIP
     SLIIYQKKDR KSVQYYSIIL KKIPPQVSVR QIEKFLDRSV QGSSQDIKRI FILYDLKEYE
     KALKERKEEV DLINQLKLEL KQVPLNQKYT DTQIKSALSL LSKRVEIELK FKEQLENKLQ
     NLQQFYINDQ QIIRIKEAPE PSDILWTGLG ATNSKQKIRI LSNIFIIISM LSSLAVIVTL
     KIIIRKSSSG YSTFWKYVFN LVAALVVALA NVSIGIIIRK MASKEQRTTQ TSYFIQVGQK
     LTQMFLVNMI LTIFFANLLA NILLPEEQNE LLNVPIDLIN LIGEYFFLFI TNSYISSIMS
     IFDIVYGFRL FQRYILQRNI RKTNCWASQQ DANSIFEGHP IDMALRYANV LKVVLYTLAI
     SVILPIGPPM CLLGLIIIYW ADKFLIYRRM VCNNYISKEL AKKMNKMLHL SPILFATGNI
     GTFALLIYNQ FDGDFNQQTL ATRDAKLTEI KKQKELSSID ETESSLEYNQ DQSSIMSSSL
     NQSEAYINWN NAKRTPYQFS NINKSQNQIQ SNQQQEIELQ NYNIQNFNTH ISNKLTIQNS
     NNNNNNNNTD SLDEKQNYLS QGTIYKSFQG QDASDFQQKL HFSNNNQINN TNNNLNTSLN
     TSTSEINKKP LNAPLLYKDI QDTEYDYKNQ TKQNQ
//