ID A0A0V0R6V1_PSEPJ Unreviewed; 521 AA.
AC A0A0V0R6V1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN ORFNames=PPERSA_07310 {ECO:0000313|EMBL:KRX10225.1};
OS Pseudocohnilembus persalinus (Ciliate).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Scuticociliatia; Philasterida; Pseudocohnilembidae;
OC Pseudocohnilembus.
OX NCBI_TaxID=266149 {ECO:0000313|EMBL:KRX10225.1, ECO:0000313|Proteomes:UP000054937};
RN [1] {ECO:0000313|EMBL:KRX10225.1, ECO:0000313|Proteomes:UP000054937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36N120E {ECO:0000313|EMBL:KRX10225.1};
RX PubMed=26486372; DOI=10.1038/srep15470;
RA Xiong J., Wang G., Cheng J., Tian M., Pan X., Warren A., Jiang C., Yuan D.,
RA Miao W.;
RT "Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus
RT persalinus provides insight into its virulence through horizontal gene
RT transfer.";
RL Sci. Rep. 5:15470-15470(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX10225.1}.
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DR EMBL; LDAU01000034; KRX10225.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0R6V1; -.
DR EnsemblProtists; KRX10225; KRX10225; PPERSA_07310.
DR InParanoid; A0A0V0R6V1; -.
DR OMA; RYMETSE; -.
DR OrthoDB; 181068at2759; -.
DR Proteomes; UP000054937; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF7; SD02261P; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054937};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 232..374
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 521 AA; 60828 MW; 0063B9B2D0742F6A CRC64;
MQNGITEPFD INDMDSIKEF IQSIDFFTFT IKNLKTSGIE DTDSISCLLW EIKIFYDFLS
YTGVQVSLQI EPGFCEGQSQ WQEVDSYIFI HAIVIILSVI SLYLGINSVY KMWKNYKMYQ
QIYIHKQKEL RNEKFNKKYT KFQTLQKQGT LSQNAKFEDF LESDSSDSDE EKVEKDEFKI
ESDSEQIERI FQYDKTFKQL STSDKMIFFN LWIIIGILGA LIQIIGSLQI IVDLTTPYEF
EAVQQNVVGI GAGIVWIIML YYLSFNPNIL GFINALEISG SKIFWFTLGV MPFFIAFLFL
FESIFWQFKW FDGTHNTIIA LFALMNGDSV NVIFSGTSSY GVIGTFFLLV YIILFFTSVQ
NVFIIIIMEG YDKMVAKQKE KIQEIKQSQQ QKKVLINDEL NTQDMQLIQN LTQQGQILEK
SDGSKEFINQ KIQLNQKLLN DQLKFIEEQF DIYINDDTFT FDYDAKSSLK LLAAEQHHEI
LQSIKLQVKK KIDHFKQLTI NLNQSRQQVS KKKKDDQTQL K
//
